Projects per year
Personal profile
Biography
I have worked in Endocrine, Nutrition and Obesity research for the past 19 years. Prior to Roehampton, the majority of my research has been carried at Imperial College, where I was a PhD student then postdoctoral fellow. After leaving Imperial College I worked as a Senior Scientist at Prosidion Ltd, a pharmaceutical company focusing on developing novel treatments for obesity and type 2 diabetes. I joined University of Roehampton in February 2012.
Qualifications
- BSc in Biochemistry with Pharmacology-The University of Southampton
- PhD in Biochemistry - Imperial College , University of London
Research interests
My research focuses on the physiological mechanisms regulating energy homeostasis. Energy homeostasis is regulated by the central nervous system, particularly the hypothalamus and brain stem. These regions are sensitive to circulating factors which signal long term energy stores and nutritional status. Peptide hormones secreted from the gastro-intestinal tract have been shown to be crucial regulators of appetite and satiety. These peptides are released into circulation from the gastrointestinal tract in response to nutritional status. In circulation they act as signals of satiety or hunger sensed by the hypothalamus and/or brainstem. My research seeks to improve our understanding of both; the mechanism behind the release of these peptides and the hypothalamic pathways through which they signal hunger or satiety. In particular I have studied the gastrointestinal peptides ghrelin, oxyntomodulin, peptide YY (PYY) and glucagon like peptide (GLP-1). Ghrelin is a peptide release from the stomach thought to act as a hunger signal; whereas oxyntomodulin, PYY and GLP-1 are all released from the gut and act as satiety signals. Improving our understanding of these gastrointestinal regulators of feeding has the potential to aid the development of novel therapies for obesity and type 2 diabetes. More recently I have focused on 3 areas; (1) The effect of chronic social stress on the neuroendocrine regulation of energy balance (2) The regulation of the novel gut hormone Prouroguanylin. (3) The role of the Thyroid hormone Beta receptor in the regulation of energy balance.
Professional affiliations
Society For Neuroendocrinology
Society for Nutrition
Teaching
I am the Programme Convenor for MSc Clinical Nutrition and MRes Nutrition and Metabolsim
Collaborations and top research areas from the last five years
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Samples on Nutrimmune project
Behrends, V., Costabile, A. & Patterson, M.
3/04/23 → …
Project: Research
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Impact of iowater on gut health and wellbeing in healthy overweight adults: a pilot human intervention study.
Costabile, A., Hepsomali, P. & Patterson, M.
1/03/23 → 31/08/23
Project: Research
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Clinical Efficacy of Brown Seaweeds Ascophyllum nodosum and Fucus vesiculosus in the Prevention or Delay Progression of the Metabolic Syndrome: A Review of Clinical Trials
Keleszade, E., Patterson, M., Trangmar, S., Guinan, K. J. & Costabile, A., 30 Jan 2021, In: Molecules (Basel, Switzerland). 26, 3Research output: Contribution to journal › Review article › peer-review
Open AccessFile92 Downloads (Pure) -
Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice
Carneiro-nascimento, S., Powell, W., Uebel, M., Buerge, M., Sigrist, H., Patterson, M., Pryce, C. R. & Opacka-juffry, J., 1 Jun 2021, In: IBRO Neuroscience Reports. 10, p. 8-16Research output: Contribution to journal › Article › peer-review
Open Access -
A pilot study to assess the effect of a fibre and mineral formulation on satiety and satiation when taken as part of a calorie restriction diet in overweight and obese women
Keleszade, E., Willner, T., Patterson, M., Trangmar, S., Kolida, S. & Costabile, A., 16 Sept 2020, In: J Func Foods. JFF-D-20-00506.Research output: Contribution to journal › Article › peer-review
Open Access -
Chronic social stress in mice alters energy status including higher glucose need but lower brain utilization
Carneiro Nascimento, S., Opacka Juffry, J., Costabile, A., Boyle, C. N., Müller Herde, A., Ametamey, S. M., Sigrist, H., Pryce, C. & Patterson, M., 5 Jun 2020, (E-pub ahead of print) In: PSYCHONEUROENDOCRINOLOGY. 119, 104747.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Downloads (Pure) -
Animal-model evidence for involvement of leptin in the regulation of stress-induced changes in energy balance
Nascimento, S., Pryce, C. R., Powell, W., Uebel, M., Opacka-Juffry, J. & Patterson, M., Aug 2019, In: British Journal of Pharmacology. 176, 16, p. 3054-3054Research output: Contribution to journal › Meeting Abstract › peer-review