Photo of Paul Allen
  • 2034 Parkstead House, Whitelands

20042019
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Personal profile

Biography

Paul Allen completed his Ph.D. in Neuropsychology (University of London) in 2005. Since then Paul has held the posts of lecturer and senior lecturer in the department of Psychosis Studies at the Institute of Psychiatry, Psychology and Neuroscience (formally the Institute of Psychiatry), King's College London where he currently holds a Visiting Professorship. Paul has co-authored over 120 papers in peer reviewed international journals on the topics of schizophrenia and psychosis, auditory verbal hallucinations and the effects of cannabis on the brain. This work has been funded by NARSAD (Brain and Behavior Research Foundation ,USA), the Medical Research Council (UK), the Wellcome Trust (UK), Guy's and St. Thomas Charitable Trust (UK) and King's Health Partners (UK). Paul's current work aims to develop and trial a real time fMRI neurofeedback system for cognitive training and clinical applications.

Qualifications

BSc, MSc, Ph.D, FHEA

Research interests

The neurobiology of Ultra High-Risk (UHR) states for psychosis

By integrating different neurocognitive and neuroimaging techniques, and working closely with the SlaM clinical service (Outreach and Support in South London; OASIS), the aim of this research is to establish predictive factors conferring elevated risk for development of psychotic illness in at-risk individuals. In particular, I have been at the forefront of a multimodal neuroimaging programme that aims to characterise neuropathology associated with psychosis at anatomical, physiological and neurochemical levels.

Neurocognitive basis of auditory verbal hallucinations

During my doctoral and post-doctoral work, I used functional neuroimaging and cognitive psychological techniques to study clinical and non-clinical subjects prone to hallucinations. I am a founding member of the International Consortium of Hallucination Research (http://hallucinationconsortium.org/) and have written three book chapters on auditory hallucinations. Currently, I am using functional Magnetic Resonance Imaging (fMRI) to developing a real-time fMRI neurofeedback system to help treat patients with refractory auditory hallucinations.

The acute neurocognitive effects of cannabis

Using neuroimaging the aim of this work is to examine the effects of acute Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration (active compounds of the cannabis plant) on cognition and associated neurofunction. In 2009 our group's work was the subject of a television documentary programme (Horizon, British Broadcasting Corporation). I am currently involved in a study investigating the potential use of CBD as a treatment for people with an UHR for psychosis funded by the Guy's and St Thomas Challenge Fund UK. It is hoped that this work will lead to more effective, specific and safer early interventions in people with early signs and symptoms of psychosis. I am also interested in the effects of early onset cannabis use on brain development and cognitive function.

Research projects

British Academy/Leverhulme Trust Small Research Grant (PI): Atttentional bias modification using Closed Loop Training: A pilot study: £9,400

Kings Health Partners 2015-2017 (PI) Real time fMRI neurofeedback as a treatment for auditory hallucinations: A proof of concept study. £100,000

NIHR Mental Health Biomedical Research Centre Neuroimaging Theme 2014-2016 (PI). Progressive factors underlying the neurobiology of psychosis. £26,000

Guy's & St Thomas Challenge Fund 2012-2013 (Co-I). A Preliminary investigation of Cannabidiol (CBD) as a novel treatment for prodromal psychosis. £99,500

National Association for Research into Schizophrenia And Depression (NARSAD) Independent Investigator Award 2010-2103: (PI). Dopamine prefrontal function and transition to psychosis. £60,000

Wellcome Trust Programme Grant (2010 - 2015): (Acting PI). Neurobiological factors underlying the onset of psychosis. £1,054,000

Guy's & St Thomas Charitable Foundation (2010-2012): (Co-I). The long-term outcome of early detection for psychosis. £98,000

Royal Society Conference Grant (2009) £1,300

Medical Research Council UK Project Grant (2008-2012): (Co-I). Social adversity, dopamine, cognition and psychosis. £872,000

NARSAD Young Investigator Award (2007-2009) (PI) Effective connectivity in individuals at high risk of psychosis. $60,000

Wellcome Trust Project Grant: Mechelli et al (2009-2011): (Co-I) Integrating functional and DTI MRI data in patients with schizophrenia. £250,000

Wellcome Trust Medical Humanities Programme Grant 2012-2017 (Colaborator). Hearing the voice (http://hearingthevoice.org/our-research-team/). £1,300,000

Professional affiliations

Schizophrenia International Research Society (SIRS)

International Early Psychosis Association (IEPA)

Links

External positions

Visiting Professor, King's College London

1 Apr 20151 Apr 2020

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2004 2019

Altered relationship between prefrontal glutamate and activation during cognitive control in people with high trait anxiety

Morgenroth, E., Orlov, N., Lythgoe, D., Stone, J., Barker, H., Munro, J., Eysenck, M. & Allen, P., 7 Mar 2019, In : Cortex. 117, August 2019, p. 53-63 11 p.

Research output: Contribution to journalArticle

Association of Adverse Outcomes, Emotion Processing and its Neural Substrate in Individuals at Clinical High Risk for Psychosis

Modinos, G., Kempton, M., Tognin, S., Antoniades, M., Azis, M., Allen, P., Borgwandt, S., McGorry, P. D., Valmaggia, L. R. & McGuire, P., 1 Sep 2019, (Accepted/In press) In : JAMA PSYCHIATRY.

Research output: Contribution to journalArticle

Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultrahigh Riskfor Psychosis

Bonoldi, I., Allen, P., Tognin, S., Bossong, M. G., Azis, M., Valmaggia, L. R., Modinos, G., Howes, O. D., Fusar-Poli, P. & McGuire, P., 10 May 2019, In : FRONTIERS IN PSYCHIATRY.

Research output: Contribution to journalArticle

Open Access
30 Downloads (Pure)

Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis

Bonoldi, I., Allen, P., Tognin, S., Bossong, M. G., Azis, M., Samson, C., Valmaggia, L. R., Modinos, G., Howes, O. D., Stone, J. & McGuire, P. K., 10 May 2019, In : FRONTIERS IN PSYCHIATRY. 10, 254

Research output: Contribution to journalArticle

Open Access
File

Cannabidiol attenuates insular dysfunction during motivational salience processing in subjects at clinical high risk for psychosis

Wilson, R., Bossong, M. G., Appiah-Kusi, E., Petros, N., Brammer, M. J., Perez, J., Allen, P., McGuire, P. & Bhattacharyya, S., 28 Jun 2019, (Accepted/In press) In : Translational Psychiatry.

Research output: Contribution to journalArticle

Activities 2012 2019

Schizophrenia International Research Society

Paul Allen (Keynote/plenary speaker)
2019

Activity: Participating in or organising an eventParticipation in conference

International Consortium of hallucination Research

Paul Allen (Keynote/plenary speaker)
Sep 2019

Activity: Participating in or organising an eventParticipation in conference

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, USA.

Paul Allen (Visiting researcher)
20182021

Activity: Visiting an external institutionVisiting an external academic institution

BBC televison and radio appearance - World News Shows

Paul Allen (Organiser)
Feb 2018

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Irish Research Council (External organisation)

Paul Allen (Chair)
20172020

Activity: MembershipMembership of board