Robert Busch

Research output

Research output per year 1989 1989 1990 1998 2002 2003 2006 2007 2010 2012 2013 2014 2019 2023

• 60 Article
• 4 Meeting Abstract
• 1 Chapter
• 1 Literature review
• 2 More
  • 1 Review article
  • 1 Working paper

Research output per year

Research output per year

Search results

• 2023

  KIR-HLA interactions extend human CD8+ T cell lifespan in vivo

  Zhang, Y., Yan, A. W. C., Boelen, L., Busch, R., Macallan, D. & Asquith, B., 16 Jun 2023, In: Journal of Clinical Investigation. 133, 12, 14 p., e169496.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  Current estimates of T-cell kinetics in humans

  Macallan, D., Busch, R. & Asquith, B., 6 Nov 2019, In: Current Opinion in Systems Biology. 18, p. 77-86

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  55 Downloads (Pure)

• HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications

  Busch, R., Kollnberger, S. & Mellins, E. D., 15 May 2019, In: Nature Reviews Rheumatology. 15, June 2019, p. 364–381

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  801 Downloads (Pure)

• Vive la difference! Self/non-self recognition and the evolution of signatures of identity in arms races with parasites

  Spottiswoode, C. & Busch, R., 11 Feb 2019, In: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. 374, 12 p., 20180206.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  140 Downloads (Pure)
• 2017

  Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment

  De Riva, A., Wallberg, M., Ronchi, F., Coulson, R., Sage, A., Thorne, L., Goodfellow, I., McCoy, K. D., Azuma, M., Cooke, A. & Busch, R., 3 Aug 2017, In: PLoS One. 12, 8, 23 p., e0181964.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  155 Downloads (Pure)
• 2016

  Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules

  Prevosto, C., Usmani, M. F., McDonald, S., Gumienny, A. M., Key, T., Goodman, R. S., Gaston, J. S. H., Deery, M. J. & Busch, R., 16 Aug 2016, In: PLoS One. 11, 8, e0161011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  273 Downloads (Pure)
• 2015

  Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease

  Ladell, K., Hazenberg, M. D., Fitch, M., Emson, C., Asgarian, B. K., Mold, J. E., Miller, C., Busch, R., Price, D. A., Hellerstein, M. K. & McCune, J. M., 2015, In: JOURNAL OF IMMUNOLOGY. 195, 9, p. 4096-4105

  Research output: Contribution to journal › Article › peer-review
• 2014

  Relationship of CD146 expression to secretion of interleukin (IL)-17, IL-22 and interferon-gamma by CD4(+) T cells in patients with inflammatory arthritis

  Wu, C., Goodall, J. C., Busch, R. & Gaston, J. S. H., 2014, In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 179, 3, p. 378-391

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  90 Downloads (Pure)

• The TRACTISS Protocol: a randomised double blind placebo controlled clinical TRial of Anti-B-Cell Therapy In patients with primary Sjögren’s Syndrome

  Brown, S., Coy, N. N., Pitzalis, C., Emery, P., Pavitt, S., Gray, J., Hulme, C., Hall, F., Busch, R., Smith, P., Dawson, L., Bombarieri, M., Wan-fai, N., Pease, C., Price, E., Sutcliffe, N., Woods, C., Ruddock, S., Everett, C. & Reynolds, C. & 6 others, Skinner, E., Poveda-Gallego, A., Rout, J., Macleod, I., Rauz, S. & Bowman, S., 2014, In: BMC MUSCULOSKELETAL DISORDERS. 15, 10 p., 21.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  125 Downloads (Pure)
• 2013

  Accelerated Turnover of MHC Class II Molecules in Nonobese Diabetic Mice Is Developmentally and Environmentally Regulated In Vivo and Dispensable for Autoimmunity

  De Riva, A., Varley, M. C., Bluck, L. J., Cooke, A., Deery, M. J. & Busch, R., 2013, In: The Journal of Immunology. 190, p. 5961-5971

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  127 Downloads (Pure)

• Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading

  Hou, T., Rinderknecht, C. H., Hadjinicolaou, A. V., Busch, R. & Mellins, E., 2013, In: Methods in molecular biology (Clifton, N.J.). 960, p. 411-32 22 p.

  Research output: Contribution to journal › Article › peer-review

• Relationship of CD146 expression to activation of circulating T cells: exploratory studies in healthy donors and patients with connective tissue diseases

  Hadjinicolaou, A. V., Wu, L., Fang, B., Watson, P. A., Hall, F. C. & Busch, R., 2013, In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 174, 1, p. 63-88

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2012

  Local activation and systemic dysregulation of T lymphocytes in Sjögren's syndrome

  Busch, R., Hadjinicolaou, A. V. & Hall, F. C., Aug 2012, In: Current pharmaceutical biotechnology. 13, 10, p. 2009-21 13 p.

  Research output: Contribution to journal › Article › peer-review

• On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes

  Busch, R., De Riva, A., Hadjinicolaou, A. V., Jiang, W., Hou, T. & Mellins, E. D., 6 Jul 2012, In: Expert reviews in molecular medicine. 14, p. e15

  Research output: Contribution to journal › Article › peer-review

• Regional Cell Proliferation in Microdissected Human Prostate Specimens after Heavy Water Labeling In Vivo: Correlation with Prostate Epithelial Cells Isolated from Seminal Fluid

  Hayes, G. M., Simko, J., Holochwost, D., Kuchinsky, K., Busch, R., Misell, L., Murphy, E. J., Carroll, P., Chan, J., Shinohara, K. & Hellerstein, M. K., 2012, In: Clinical Cancer Research. 18, 12, p. 3250-3260

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2011

  Potential biomarkers of monocyte/macrophage activity in a patient with sarcoidosis, treated with infliximab

  Fang, B., Bhagat, S., Busch, R., Parfrey, H. & Hall, F. C., May 2011, In: Rheumatology (Oxford, England). 50, 5, p. 992-4 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms

  Rinderknecht, C. H., Roh, S., Pashine, A., Belmares, M. P., Patil, N. S., Lu, N., Truong, P., Hou, T., Macaubas, C., Yoon, T., Wang, N., Busch, R. & Mellins, E. D., Sept 2010, In: IMMUNOLOGY. 131, 1, p. 18-32 15 p.

  Research output: Contribution to journal › Article › peer-review

• Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies

  Hayes, G. M., Busch, R., Voogt, J., Siah, I. M., Gee, T. A., Hellerstein, M. K., Chiorazzi, N., Rai, K. R. & Murphy, E. J., Jun 2010, In: Leukemia research. 34, 6, p. 809-15 7 p.

  Research output: Contribution to journal › Article › peer-review

• Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules

  Burster, T., Macmillan, H., Hou, T., Schilling, J., Truong, P., Boehm, B. O., Zou, F., Lau, K., Strohman, M., Schaffert, S., Busch, R. & Mellins, E. D., Jul 2010, In: IMMUNOLOGY. 130, 3, p. 436-46 11 p.

  Research output: Contribution to journal › Article › peer-review

• Measurement of protein synthesis using heavy water labeling and peptide mass spectrometry: Discrimination between major histocompatibility complex allotypes

  De Riva, A., Deery, M. J., McDonald, S., Lund, T. & Busch, R., 2010, In: Analytical Biochemistry. 403, 1-2, p. 1-12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  109 Downloads (Pure)
• 2008

  Central Memory CD8+ T Cells Appear to Have a Shorter Lifespan and Reduced Abundance as a Function of HIV Disease Progression

  Ladell, K., Hellerstein, M. K., Cesar, D., Busch, R., Boban, D. & McCune, J. M., 2008, In: The Journal of Immunology. 180, 12, p. 7907-7918

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Heavy water labeling of DNA for measurement of cell proliferation and recruitment during primary murine lymph node responses against model antigens

  Busch, R., Siah, I. M., Gee, T. A. & Hellerstein, M. K., 20 Aug 2008, In: Journal of immunological methods. 337, 1, p. 24-34 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: application to drug discovery

  Shankaran, M., Marino, M. E., Busch, R., Keim, C., King, C., Lee, J., Killion, S., Awada, M. & Hellerstein, M. K., 15 Aug 2007, In: JOURNAL OF NEUROSCIENCE RESEARCH. 85, 11, p. 2374-84 11 p.

  Research output: Contribution to journal › Article › peer-review

• Measurement of cell proliferation by heavy water labeling

  Busch, R., Neese, R. A., Awada, M., Hayes, G. M. & Hellerstein, M. K., 2007, In: Nature protocols. 2, 12, p. 3045-57 13 p.

  Research output: Contribution to journal › Article › peer-review

• Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography/pyrolysis/isotope ratio-mass spectrometric analysis

  Voogt, J. N., Awada, M., Murphy, E. J., Hayes, G. M., Busch, R. & Hellerstein, M. K., 2007, In: Nature protocols. 2, 12, p. 3058-62 5 p.

  Research output: Contribution to journal › Article › peer-review

• Posttranslational regulation of I-Ed by affinity for CLIP

  Rinderknecht, C. H., Belmares, M. P., Catanzarite, T. L. W., Bankovich, A. J., Holmes, T. H., Garcia, K. C., Nanda, N. K., Busch, R., Kovats, S. & Mellins, E. D., 1 Nov 2007, In: The Journal of Immunology. 179, 9, p. 5907-15 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique

  Shankaran, M., King, C., Lee, J., Busch, R., Wolff, M. & Hellerstein, M. K., Dec 2006, In: The Journal of pharmacology and experimental therapeutics. 319, 3, p. 1172-81 10 p.

  Research output: Contribution to journal › Article › peer-review

• Measurement of protein turnover rates by heavy water labeling of nonessential amino acids

  Busch, R., Kim, Y.-K., Neese, R. A., Schade-Serin, V., Collins, M., Awada, M., Gardner, J. L., Beysen, C., Marino, M. E., Misell, L. M. & Hellerstein, M. K., May 2006, In: Biochimica et biophysica acta. 1760, 5, p. 730-44 15 p.

  Research output: Contribution to journal › Article › peer-review

• Medicine on a need-to-know basis

  Busch, R., Byrne, B., Gandrud, L., Sears, D., Meyer, E., Kattah, M., Kurihara, C., Haertel, E., Parnes, J. R. & Mellins, E. D., Jun 2006, In: Current protocols in immunology. 7, 6, p. 543-7 5 p.

  Research output: Contribution to journal › Article
• 2005

  Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression

  Busch, R., Rinderknecht, C. H., Roh, S., Lee, A. W., Harding, J. J., Burster, T., Hornell, T. M. C. & Mellins, E. D., Oct 2005, In: Immunological Reviews. 207, p. 242-60 19 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes

  Fanara, P., Turner, S., Busch, R., Killion, S., Awada, M., Turner, H., Mahsut, A., Laprade, K. L., Stark, J. M. & Hellerstein, M. K., 26 Nov 2004, In: JOURNAL OF BIOLOGICAL CHEMISTRY. 279, 48, p. 49940-7 8 p.

  Research output: Contribution to journal › Article › peer-review

• Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling

  Busch, R., Cesar, D., Higuera-Alhino, D., Gee, T., Hellerstein, M. K. & McCune, J. M., Mar 2004, In: Journal of immunological methods. 286, 1-2, p. 97-109 13 p.

  Research output: Contribution to journal › Article › peer-review
• 2003

  Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM

  Belmares, M. P., Busch, R., Mellins, E. D. & McConnell, H. M., 28 Jan 2003, In: Biochemistry. 42, 3, p. 838-47 10 p.

  Research output: Contribution to journal › Article › peer-review

• Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides

  Pashine, A., Busch, R., Belmares, M. P., Munning, J. N., Doebele, R. C., Buckingham, M., Nolan, G. P. & Mellins, E. D., Aug 2003, In: Infection and immunity. 19, 2, p. 183-92 10 p.

  Research output: Contribution to journal › Article › peer-review

• Point mutations in or near the antigen-binding groove of HLA-DR3 implicate class II-associated invariant chain peptide affinity as a constraint on MHC class II polymorphism

  Doebele, R. C., Pashine, A., Liu, W., Zaller, D. M., Belmares, M., Busch, R. & Mellins, E. D., 1 May 2003, In: The Journal of Immunology. 170, 9, p. 4683-92 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2002

  Relationship between kinetic stability and immunogenicity of HLA-DR4/peptide complexes

  Hall, F. C., Rabinowitz, J. D., Busch, R., Visconti, K. C., Belmares, M., Patil, N. S., Cope, A. P., Patel, S., McConnell, H. M., Mellins, E. D. & Sonderstrup, G., Mar 2002, In: Current protocols in immunology. 32, 3, p. 662-70 9 p.

  Research output: Contribution to journal › Article › peer-review

• Stabilization of soluble, low-affinity HLA-DM/HLA-DR1 complexes by leucine zippers

  Busch, R., Pashine, A., Garcia, K. C. & Mellins, E. D., 1 May 2002, In: Journal of immunological methods. 263, 1-2, p. 111-21 11 p.

  Research output: Contribution to journal › Article › peer-review

• Structural factors contributing to DM susceptibility of MHC class II/peptide complexes

  Belmares, M. P., Busch, R., Wucherpfennig, K. W., McConnell, H. M. & Mellins, E. D., 1 Nov 2002, In: The Journal of Immunology. 169, 9, p. 5109-17 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2001

  Binding of biotinylated peptides to MHC class II proteins on cell surfaces

  Rothbard, J. B. & Busch, R., May 2001, In: Current protocols in immunology. Chapter 18, p. Unit 18.1

  Research output: Contribution to journal › Article › peer-review

• The kinetic basis of peptide exchange catalysis by HLA-DM

  Zarutskie, J. A., Busch, R., Zavala-Ruiz, Z., Rushe, M., Mellins, E. D. & Stern, L. J., 23 Oct 2001, In: PNAS: Proceedings of the National Academy of Sciences. 98, 22, p. 12450-5 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2000

  Accessory molecules for MHC class II peptide loading

  Busch, R., Doebele, R. C., Patil, N. S., Pashine, A. & Mellins, E. D., Feb 2000, In: Current opinion in immunology. 12, 1, p. 99-106 8 p.

  Research output: Contribution to journal › Article › peer-review

• Determination of the HLA-DM interaction site on HLA-DR molecules

  Doebele, R. C., Busch, R., Scott, H. M., Pashine, A. & Mellins, E. D., Oct 2000, In: Infection and immunity. 13, 4, p. 517-27 11 p.

  Research output: Contribution to journal › Article › peer-review
• 1998

  Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function

  Busch, R., Doebele, R. C., von Scheven, E., Fahrni, J. & Mellins, E. D., 15 Jan 1998, In: The Journal of Immunology. 160, 2, p. 734-43 10 p.

  Research output: Contribution to journal › Article › peer-review

• Novel glycosylation of HLA-DRalpha disrupts antigen presentation without altering endosomal localization

  Guerra, C. B., Busch, R., Doebele, R. C., Liu, W., Sawada, T., Kwok, W. W., Chang, M. D. & Mellins, E. D., 1 May 1998, In: The Journal of Immunology. 160, 9, p. 4289-97 9 p.

  Research output: Contribution to journal › Article › peer-review

• Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM

  Busch, R., Reich, Z., Zaller, D. M., Sloan, V. & Mellins, E. D., 16 Oct 1998, In: JOURNAL OF BIOLOGICAL CHEMISTRY. 273, 42, p. 27557-64 8 p.

  Research output: Contribution to journal › Article › peer-review
• 1996

  Developing and shedding inhibitions: how MHC class II molecules reach maturity

  Busch, R. & Mellins, E. D., Feb 1996, In: Current opinion in immunology. 8, 1, p. 51-8 8 p.

  Research output: Contribution to journal › Article › peer-review

• Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum

  Busch, R., Cloutier, I., Sékaly, R. P. & Hämmerling, G. J., 15 Jan 1996, In: The EMBO Journal. 15, 2, p. 418-28 11 p.

  Research output: Contribution to journal › Article › peer-review
• 1995

  Poor loading of major histocompatibility complex class II molecules with endogenously synthesized short peptides in the absence of invariant chain

  Busch, R., Vturina, I. Y., Drexler, J., Momburg, F. & Hämmerling, G. J., Jan 1995, In: Current opinion in immunology. 25, 1, p. 48-53 6 p.

  Research output: Contribution to journal › Article › peer-review
• 1993

  Epitope-specific enhancement of antigen presentation by invariant chain

  Momburg, F., Fuchs, S., Drexler, J., Busch, R., Post, M., Hämmerling, G. J. & Adorini, L., 1 Oct 1993, In: Journal of Experimental Medicine. 178, 4, p. 1453-8 6 p.

  Research output: Contribution to journal › Article › peer-review
• 1991

  An in vitro model of peptide-mediated immunomodulation of the human T cell response to Dermatophagoides spp (house dust mite)

  O'Hehir, R. E., Busch, R., Rothbard, J. B. & Lamb, J. R., Jun 1991, In: The Journal of allergy and clinical immunology. 87, 6, p. 1120-7 8 p.

  Research output: Contribution to journal › Article › peer-review