A prebiotic intervention study in children with Autism Spectrum Disorders (ASDs).

Roberta Grimaldi, Glenn R Gibson, Jelena Vulevic, Natasa Giallourou, Josue L Castro-Mejia, Lars H Hansen, Edward Leigh Gibson, Dennis S Nielsen, Adele Costabile

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Abstract

Background: Different dietary approaches, such as gluten and casein free diets, or the use of probiotics and prebiotics have been suggested in autistic spectrum disorders in order to reduce gastrointestinal (GI) disturbances. GI symptoms are of particular interest in this population due to prevalence and correlation with the severity of behavioural traits. Nowadays, there is lack of strong evidence about the effect of dietary interventions on these problems, particularly prebiotics. Therefore, we assessed the impact of exclusion diets and a 6-week Bimuno® galactooligosaccharide (B-GOS®) prebiotic intervention in 30 autistic children.
Results: The results showed that children on exclusion diets reported significantly lower scores of abdominal pain and bowel movement, as well as lower abundance of Bifidobacterium spp. and Veillonellaceae family, but higher presence of Faecalibacterium prausnitzii and Bacteroides spp. In addition, significant correlations were found between bacterial populations and faecal amino acids in this group, compared to children following an unrestricted diet. Following B-GOS® intervention, we observed improvements in anti-social behaviour, significant increase of Lachnospiraceae family, and significant changes in faecal and urine metabolites.
Conclusions: To our knowledge, this is the first study where the effect of exclusion diets and prebiotics has been evaluated in autism, showing potential beneficial effects. A combined dietary approach resulted in significant changes in gut microbiota composition and metabolism suggesting that multiple interventions might be more relevant for the improvement of these aspects as well as psychological traits.
Trial registration: NCT02720900; registered in November 2015.

© 2018 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/
Original languageEnglish
Article numberMBIO-D-18-00132R2
Pages (from-to)133-145
Number of pages13
JournalMicrobiome
Volume6
Issue number133
Early online date2 Aug 2018
DOIs
Publication statusE-pub ahead of print - 2 Aug 2018

Keywords

  • Autism
  • GOS
  • Microbiota
  • Prebiotics
  • Gut symptoms
  • Sequencing
  • H-NMR

Cite this

Grimaldi, R., Gibson, G. R., Vulevic, J., Giallourou, N., Castro-Mejia, J. L., Hansen, L. H., Gibson, E. L., Nielsen, D. S., & Costabile, A. (2018). A prebiotic intervention study in children with Autism Spectrum Disorders (ASDs). Microbiome, 6(133), 133-145. [MBIO-D-18-00132R2]. https://doi.org/10.1186/s40168-018-0523-3