A systematic review of multisensory cognitive-affective integration in schizophrenia

Huai-Hsuan Tseng; Matthijs G. Bossong; Gemma Modinos; Kuan-Ming Chen; Philip McGuire; Paul Allen

doi:10.1016/j.neubiorev.2015.04.019

A systematic review of multisensory cognitive-affective integration in schizophrenia

Huai-Hsuan Tseng, Matthijs G. Bossong, Gemma Modinos, Kuan-Ming Chen, Philip McGuire, Paul Allen

Research output: Contribution to journal › Article › peer-review

Abstract

The etymology of schizophrenia implies poor functional integration of sensory, cognitive and affective processes. Multisensory integration (MSI) is a spontaneous perceptual-cognitive process by which relevant information from multiple sensory modalities is extracted to generate a holistic experience. Deficits in MSI may hinder prompt and appropriate behavioural responses in a complex and transient environment. Despite extensive investigation of sensory, cognitive and affective processing in patients with schizophrenia, little is known about how MSI is affected in the illness. We systemically searched the PubMed electronic database and reviewed twenty-nine behavioural and neuroimaging studies examining MSI in patients with schizophrenia. The available evidence indicates impaired MSI for non-emotional stimuli in schizophrenia, especially for linguistic information. There is also evidence for altered MSI for emotional stimuli, although findings are inconsistent and may be modality-specific. Brain functional alterations in the superior temporal cortex and inferior frontal cortex appear to underlie the deficits in both non-emotional and emotional MSI. The limitations of the experimental paradigms used and directions for future research are also discussed. (C) 2015 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	444-452
Journal	Neuroscience & Biobehavioral Reviews
Volume	55
DOIs	https://doi.org/10.1016/j.neubiorev.2015.04.019
Publication status	Published - 2015

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10.1016/j.neubiorev.2015.04.019

http://dx.doi.org/10.1016/j.neubiorev.2015.04.019

Cite this

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title = "A systematic review of multisensory cognitive-affective integration in schizophrenia",

abstract = "The etymology of schizophrenia implies poor functional integration of sensory, cognitive and affective processes. Multisensory integration (MSI) is a spontaneous perceptual-cognitive process by which relevant information from multiple sensory modalities is extracted to generate a holistic experience. Deficits in MSI may hinder prompt and appropriate behavioural responses in a complex and transient environment. Despite extensive investigation of sensory, cognitive and affective processing in patients with schizophrenia, little is known about how MSI is affected in the illness. We systemically searched the PubMed electronic database and reviewed twenty-nine behavioural and neuroimaging studies examining MSI in patients with schizophrenia. The available evidence indicates impaired MSI for non-emotional stimuli in schizophrenia, especially for linguistic information. There is also evidence for altered MSI for emotional stimuli, although findings are inconsistent and may be modality-specific. Brain functional alterations in the superior temporal cortex and inferior frontal cortex appear to underlie the deficits in both non-emotional and emotional MSI. The limitations of the experimental paradigms used and directions for future research are also discussed. (C) 2015 Elsevier Ltd. All rights reserved.",

author = "Huai-Hsuan Tseng and Bossong, {Matthijs G.} and Gemma Modinos and Kuan-Ming Chen and Philip McGuire and Paul Allen",

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AU - Tseng, Huai-Hsuan

AU - Bossong, Matthijs G.

AU - Modinos, Gemma

AU - Chen, Kuan-Ming

AU - McGuire, Philip

AU - Allen, Paul

PY - 2015

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AB - The etymology of schizophrenia implies poor functional integration of sensory, cognitive and affective processes. Multisensory integration (MSI) is a spontaneous perceptual-cognitive process by which relevant information from multiple sensory modalities is extracted to generate a holistic experience. Deficits in MSI may hinder prompt and appropriate behavioural responses in a complex and transient environment. Despite extensive investigation of sensory, cognitive and affective processing in patients with schizophrenia, little is known about how MSI is affected in the illness. We systemically searched the PubMed electronic database and reviewed twenty-nine behavioural and neuroimaging studies examining MSI in patients with schizophrenia. The available evidence indicates impaired MSI for non-emotional stimuli in schizophrenia, especially for linguistic information. There is also evidence for altered MSI for emotional stimuli, although findings are inconsistent and may be modality-specific. Brain functional alterations in the superior temporal cortex and inferior frontal cortex appear to underlie the deficits in both non-emotional and emotional MSI. The limitations of the experimental paradigms used and directions for future research are also discussed. (C) 2015 Elsevier Ltd. All rights reserved.

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