Annexin A1 and glucocorticoids as effectors of the resolution of inflammation

Mauro Perretti, Fulvio D'Acquisto

Research output: Contribution to journalReview articlepeer-review


Glucocorticoids are widely used for the management of inflammatory diseases. Their clinical application stems from our understanding of the inhibitory effect of the corticosteroid hormone cortisol on several components of the immune system. Endogenous and exogenous glucocorticoids mediate their multiple anti-inflammatory effects through many effector molecules. In this Opinion article, we focus on the role of one such effector molecule, annexin A1, and summarize the recent studies that provide insight into its molecular and pharmacological functions in immune responses. In addition, we propose a model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation.

Original languageEnglish
Pages (from-to)62-70
Number of pages9
JournalCurrent opinion in immunology
Issue number1
Publication statusPublished - Jan 2009


  • Animals
  • Annexin A1
  • Anti-Inflammatory Agents
  • Circadian Rhythm
  • Gene Expression Regulation
  • Glucocorticoids
  • Humans
  • Hydrocortisone
  • Immune System
  • Immunity, Innate
  • Inflammation
  • Lipoxins
  • Macrophages
  • Mice
  • Mice, Knockout
  • Models, Immunological
  • Monocytes
  • Neutrophils
  • Receptors, Formyl Peptide
  • Receptors, Lipoxin
  • T-Lymphocyte Subsets
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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