Chapter 4: Adaptive Immunity

Elizbeth C. Rosser; Robert Busch; Elizabeth D Mellins; Robert  Fuhlbrigge

Chapter 4: Adaptive Immunity

Elizbeth C. Rosser, Robert Busch, Elizabeth D Mellins, Robert Fuhlbrigge

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In this chapter we provide a brief overview of the cells and mechanisms involved in mediating adaptive immunity. We review T cell development and effector functions, with a focus on how T cell dysfunction contributes to pathology in pediatric rheumatological conditions. We also discuss B cell development and effector functions, including antibody and cytokine production and their contributions to immune dysregulation. Finally, we discuss antigen presentation via MHC class I and class II, which acts as a bridge between T and B cell responses, with a focus on potential therapeutic targets.

Original language	English
Title of host publication	Textbook of Pediatric Rheumatology
Editors	Ross E. Petty, Ronald M. Laxer, Carol B. Lindsley, Lucy Wedderburn, Robert C. Fuhlbrigge, Elizabeth D. Mellins
Publisher	Elsevier
Number of pages	50
Edition	9th ed.
Publication status	Submitted - 7 Oct 2024

Cite this

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title = "Chapter 4: Adaptive Immunity",

abstract = "In this chapter we provide a brief overview of the cells and mechanisms involved in mediating adaptive immunity. We review T cell development and effector functions, with a focus on how T cell dysfunction contributes to pathology in pediatric rheumatological conditions. We also discuss B cell development and effector functions, including antibody and cytokine production and their contributions to immune dysregulation. Finally, we discuss antigen presentation via MHC class I and class II, which acts as a bridge between T and B cell responses, with a focus on potential therapeutic targets.",

author = "Rosser, {Elizbeth C.} and Robert Busch and Mellins, {Elizabeth D} and Robert Fuhlbrigge",

note = "9th ed. is yet to be published. The 8th edition had hardback ISBN 9780323636520 and eBook ISBN 9780443352065.",

year = "2024",

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language = "English",

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publisher = "Elsevier",

address = "Netherlands",

edition = "9th ed.",

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T1 - Chapter 4: Adaptive Immunity

AU - Rosser, Elizbeth C.

AU - Busch, Robert

AU - Mellins, Elizabeth D

AU - Fuhlbrigge, Robert

N1 - 9th ed. is yet to be published. The 8th edition had hardback ISBN 9780323636520 and eBook ISBN 9780443352065.

PY - 2024/10/7

Y1 - 2024/10/7

N2 - In this chapter we provide a brief overview of the cells and mechanisms involved in mediating adaptive immunity. We review T cell development and effector functions, with a focus on how T cell dysfunction contributes to pathology in pediatric rheumatological conditions. We also discuss B cell development and effector functions, including antibody and cytokine production and their contributions to immune dysregulation. Finally, we discuss antigen presentation via MHC class I and class II, which acts as a bridge between T and B cell responses, with a focus on potential therapeutic targets.

AB - In this chapter we provide a brief overview of the cells and mechanisms involved in mediating adaptive immunity. We review T cell development and effector functions, with a focus on how T cell dysfunction contributes to pathology in pediatric rheumatological conditions. We also discuss B cell development and effector functions, including antibody and cytokine production and their contributions to immune dysregulation. Finally, we discuss antigen presentation via MHC class I and class II, which acts as a bridge between T and B cell responses, with a focus on potential therapeutic targets.

M3 - Chapter

BT - Textbook of Pediatric Rheumatology

A2 - Petty, Ross E.

A2 - Laxer, Ronald M.

A2 - Lindsley, Carol B.

A2 - Wedderburn, Lucy

A2 - Fuhlbrigge, Robert C.

A2 - Mellins, Elizabeth D.

PB - Elsevier

ER -