TY - JOUR
T1 - Clinical Efficacy of Brown Seaweeds Ascophyllum nodosum and Fucus vesiculosus in the Prevention or Delay Progression of the Metabolic Syndrome: A Review of Clinical Trials
AU - Keleszade, Enver
AU - Patterson, Michael
AU - Trangmar, Steven
AU - Guinan, Kieran J
AU - Costabile, Adele
PY - 2021/1/30
Y1 - 2021/1/30
N2 - Metabolic syndrome (MetS) is a global public health problem affecting nearly 25.9% of the world population characterised by a cluster of disorders dominated by abdominal obesity, high blood pressure, high fasting plasma glucose, hypertriacylglycerolaemia and low HDL-cholesterol. In recent years, marine organisms, especially seaweeds, have been highlighted as potential natural sources of bioactive compounds and useful metabolites, with many biological and physiological activities to be used in functional foods or in human nutraceuticals for the management of MetS and related disorders. Of the three groups of seaweeds, brown seaweeds are known to contain more bioactive components than either red and green seaweeds. Among the different brown seaweed species, Ascophyllum nodosum and Fucus vesiculosus have the highest antioxidant values and highest total phenolic content. However, the evidence base relies mainly on cell line and small animal models, with few studies to date involving humans. This review intends to provide an overview of the potential of brown seaweed extracts Ascophyllum nodosum and Fucus vesiculosus for the management and prevention of MetS and related conditions, based on the available evidence obtained from clinical trials.© 2021, The Author(s).
This is an open-access article distributed under the terms of the Creative
Commons Attribution 4.0 International License (CC BY 4.0), which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited. See http://creativecommons.org/licenses/by/4.0/
AB - Metabolic syndrome (MetS) is a global public health problem affecting nearly 25.9% of the world population characterised by a cluster of disorders dominated by abdominal obesity, high blood pressure, high fasting plasma glucose, hypertriacylglycerolaemia and low HDL-cholesterol. In recent years, marine organisms, especially seaweeds, have been highlighted as potential natural sources of bioactive compounds and useful metabolites, with many biological and physiological activities to be used in functional foods or in human nutraceuticals for the management of MetS and related disorders. Of the three groups of seaweeds, brown seaweeds are known to contain more bioactive components than either red and green seaweeds. Among the different brown seaweed species, Ascophyllum nodosum and Fucus vesiculosus have the highest antioxidant values and highest total phenolic content. However, the evidence base relies mainly on cell line and small animal models, with few studies to date involving humans. This review intends to provide an overview of the potential of brown seaweed extracts Ascophyllum nodosum and Fucus vesiculosus for the management and prevention of MetS and related conditions, based on the available evidence obtained from clinical trials.© 2021, The Author(s).
This is an open-access article distributed under the terms of the Creative
Commons Attribution 4.0 International License (CC BY 4.0), which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited. See http://creativecommons.org/licenses/by/4.0/
U2 - 10.3390/molecules26030714
DO - 10.3390/molecules26030714
M3 - Review article
C2 - 33573121
SN - 1420-3049
VL - 26
JO - Molecules (Basel, Switzerland)
JF - Molecules (Basel, Switzerland)
IS - 3
ER -