Coffee, type 2 diabetes and pancreatic islet function - a mini-review

TY - JOUR

T1 - Coffee, type 2 diabetes and pancreatic islet function - a mini-review

AU - Costabile, Adele

AU - Sarnsamak, Kittiwadee

AU - Hauge-Evans, A.C.

PY - 2018/4/21

Y1 - 2018/4/21

N2 - Caffeinated and decaffeinated coffee consumption has increasingly been linked to reduced risks of type 2 diabetes. The condition is characterised by insulin resistance and pancreatic beta cell loss and dysfunction, leading to hyperglycaemia. Recent research has indicated that coffee components such as chlorogenic acid derivatives and cafestol positively modify the regulation of blood glucose levels in peripheral tissues. Taking into consideration bioavailability of coffee bioactives, this mini-review evaluates the pros and cons of individual components and their combinations and highlights some of their significant effects on insulin secretion. Although the loss and/or dysfunction of beta cells is a key element in type 2 diabetes, little is known about the impact of coffee components on the regulation of beta cell mass, including survival under conditions of hyperglycaemia, lipotoxicity and inflammation. Further investigations are warranted in particular with regards to use of physiologicallyrelevant concentrations and conjugated forms of the bioactive components.© 2018, Elsevier. This is an author produced version of a paper published in JOURNAL OF FUNCTIONAL FOODS uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link below. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it.

AB - Caffeinated and decaffeinated coffee consumption has increasingly been linked to reduced risks of type 2 diabetes. The condition is characterised by insulin resistance and pancreatic beta cell loss and dysfunction, leading to hyperglycaemia. Recent research has indicated that coffee components such as chlorogenic acid derivatives and cafestol positively modify the regulation of blood glucose levels in peripheral tissues. Taking into consideration bioavailability of coffee bioactives, this mini-review evaluates the pros and cons of individual components and their combinations and highlights some of their significant effects on insulin secretion. Although the loss and/or dysfunction of beta cells is a key element in type 2 diabetes, little is known about the impact of coffee components on the regulation of beta cell mass, including survival under conditions of hyperglycaemia, lipotoxicity and inflammation. Further investigations are warranted in particular with regards to use of physiologicallyrelevant concentrations and conjugated forms of the bioactive components.© 2018, Elsevier. This is an author produced version of a paper published in JOURNAL OF FUNCTIONAL FOODS uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link below. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it.

KW - Coffee

KW - Type 2 diabetes

KW - Islet

KW - Beta cell function

KW - Chlorogenic acids

U2 - 10.1016/j.jff.2018.04.011

DO - 10.1016/j.jff.2018.04.011

M3 - Article

SN - 1756-4646

VL - 45

SP - 409

EP - 416

JO - JOURNAL OF FUNCTIONAL FOODS

JF - JOURNAL OF FUNCTIONAL FOODS

ER -