Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function in older women

Paul Fairbairn, Fotini Tsofliou, Andrew Johnson, Simon Dyall

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Abstract

Omega-3 PUFAs, B vitamins, vitamin E, phosphatidylserine, and Ginkgo Biloba were promising in preserving mobility and cognitive function in older adults. Exercise benefits mobility and there is evidence suggesting positive interactions between exercise and omega-3 PUFAs.
Non-frail or pre-frail females aged ≥60 years are included in a randomised placebo controlled study. Intervention groups are: multi-nutrient supplement and exercise, placebo supplement and exercise, multi-nutrient supplement, and placebo supplement. Dietary supplementation is 24 weeks. The exercise intervention, two cycle ergometer classes per week, is for 12 weeks. The primary outcome is habitual walking speed, secondary outcomes include gait variables under single and dual task, five times sit to stand, verbal and spatial memory, executive function, interference control and health related quality of life. Blood fatty acids, serum homocysteine, dietary intake, physical activity, and verbal intelligence are measured to assess compliance and control for confounding factors. The study is registered at www.clinicaltrials.gov (NCT03228550).

© 2019, Elsevier. The attached document (embargoed until 01/04/2020) is an author produced version of a paper published in PROSTAGLANDINS, LEUKOTRIENES AND ESSENTIAL FATTY ACIDS uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it.
Original languageEnglish
Pages (from-to)21-30
JournalProstaglandins, leukotrienes, and essential fatty acids
Volume143
DOIs
Publication statusPublished - 1 Apr 2019

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