Background: Although parental stress is higher for children with neurodevelopmental disorders (NDs), it is unclear how this stress compares to more common NDs. The current study compared stress in parents of children with Williams Syndrome (WS), Down Syndrome (DS), and Autism Spectrum Disorders (ASD). The impact of individual and contextual factors was also explored. Method: Parents of children with WS (n = 107), DS (n = 79), and ASD (n = 79) completed a background questionnaire, a parental stress questionnaire, and a satisfaction with life questionnaire. Results: Although all groups displayed similar levels of parental stress, the factors that influenced this stress differed between the groups. There were also differences for life satisfaction and relationships between parental stress and individual and contextual factors. Conclusions: Although parents of children with NDs are not at an increased risk for parental stress, the results suggest that interventions should be syndrome specific. © 2019, John Wiley & Sons Ltd. The attached document (embargoed until 05/04/2020) is an author produced version of a paper published in JOURNAL OF INTELLECTUAL DISABILITY RESEARCH uploaded in accordance with the publisher’s self- archiving policy. The final published version (version of record) is available online at the link below. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it.