Different duration of at-risk mental state associated with neurofunctional abnormalities.: A multimodal imaging study

Renata Smieskova; Paul Allen; Andor Simon; Jacqueline Aston; Kerstin Bendfeldt; Juergen Drewe; Kerstin Gruber; Ute Gschwandtner; Markus Klarhoefer; Claudia Lenz; Klaus Scheffler; Rolf-Dieter Stieglitz; Ernst-Wilhelm Radue; Philip McGuire; Anita Riecher-Roessler; Stefan J. Borgwardt

doi:10.1002/hbm.21360

Different duration of at-risk mental state associated with neurofunctional abnormalities. A multimodal imaging study

Renata Smieskova, Paul Allen, Andor Simon, Jacqueline Aston, Kerstin Bendfeldt, Juergen Drewe, Kerstin Gruber, Ute Gschwandtner, Markus Klarhoefer, Claudia Lenz, Klaus Scheffler, Rolf-Dieter Stieglitz, Ernst-Wilhelm Radue, Philip McGuire, Anita Riecher-Roessler, Stefan J. Borgwardt

Research output: Contribution to journal › Article

Abstract

Objectives: Neurofunctional alterations are correlates of vulnerability to psychosis, as well as of the disorder itself. How these abnormalities relate to different probabilities for later transition to psychosis is unclear. We investigated vulnerability- versus disease-related versus resilience biomarkers of psychosis during working memory (WM) processing in individuals with an at-risk mental state (ARMS). Experimental design: Patients with first-episode psychosis (FEP, n = 21), short-term ARMS (ARMS-ST, n = 17), long-term ARMS (ARMS-LT, n = 16), and healthy controls (HC, n = 20) were investigated with an n-back WM task. We examined functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) data in conjunction using biological parametric mapping (BPM) toolbox. Principal observations: There were no differences in accuracy, but the FEP and the ARMS-ST group had longer reaction times compared with the HC and the ARMS-LT group. With the 2-back > 0-back contrast, we found reduced functional activation in ARMS-ST and FEP compared with the HC group in parietal and middle frontal regions. Relative to ARMS-LT individuals, FEP patients showed decreased activation in the bilateral inferior frontal gyrus and insula, and in the left prefrontal cortex. Compared with the ARMS-LT, the ARMS-ST subjects showed reduced activation in the right inferior frontal gyrus and insula. Reduced insular and prefrontal activation was associated with gray matter volume reduction in the same area in the ARMS-LT group. Conclusions: These findings suggest that vulnerability to psychosis was associated with neurofunctional alterations in fronto-temporo-parietal networks in a WM task. Neurofunctional differences within the ARMS were related to different duration of the prodromal state and resilience factors. Hum Brain Mapp 33:22812294, 2012. (c) 2011 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	2281-2294
Journal	HUMAN BRAIN MAPPING
Volume	33
Issue number	10
DOIs	https://doi.org/10.1002/hbm.21360
Publication status	Published - 2012

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10.1002/hbm.21360

http://dx.doi.org/10.1002/hbm.21360

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Smieskova, R., Allen, P., Simon, A., Aston, J., Bendfeldt, K., Drewe, J., Gruber, K., Gschwandtner, U., Klarhoefer, M., Lenz, C., Scheffler, K., Stieglitz, R.-D., Radue, E.-W., McGuire, P., Riecher-Roessler, A., & Borgwardt, S. J. (2012). Different duration of at-risk mental state associated with neurofunctional abnormalities. A multimodal imaging study. HUMAN BRAIN MAPPING, 33(10), 2281-2294. https://doi.org/10.1002/hbm.21360

@article{1668e821260a4a0297961eff018fe79b,

title = "Different duration of at-risk mental state associated with neurofunctional abnormalities.: A multimodal imaging study",

abstract = "Objectives: Neurofunctional alterations are correlates of vulnerability to psychosis, as well as of the disorder itself. How these abnormalities relate to different probabilities for later transition to psychosis is unclear. We investigated vulnerability- versus disease-related versus resilience biomarkers of psychosis during working memory (WM) processing in individuals with an at-risk mental state (ARMS). Experimental design: Patients with first-episode psychosis (FEP, n = 21), short-term ARMS (ARMS-ST, n = 17), long-term ARMS (ARMS-LT, n = 16), and healthy controls (HC, n = 20) were investigated with an n-back WM task. We examined functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) data in conjunction using biological parametric mapping (BPM) toolbox. Principal observations: There were no differences in accuracy, but the FEP and the ARMS-ST group had longer reaction times compared with the HC and the ARMS-LT group. With the 2-back > 0-back contrast, we found reduced functional activation in ARMS-ST and FEP compared with the HC group in parietal and middle frontal regions. Relative to ARMS-LT individuals, FEP patients showed decreased activation in the bilateral inferior frontal gyrus and insula, and in the left prefrontal cortex. Compared with the ARMS-LT, the ARMS-ST subjects showed reduced activation in the right inferior frontal gyrus and insula. Reduced insular and prefrontal activation was associated with gray matter volume reduction in the same area in the ARMS-LT group. Conclusions: These findings suggest that vulnerability to psychosis was associated with neurofunctional alterations in fronto-temporo-parietal networks in a WM task. Neurofunctional differences within the ARMS were related to different duration of the prodromal state and resilience factors. Hum Brain Mapp 33:22812294, 2012. (c) 2011 Wiley Periodicals, Inc.",

author = "Renata Smieskova and Paul Allen and Andor Simon and Jacqueline Aston and Kerstin Bendfeldt and Juergen Drewe and Kerstin Gruber and Ute Gschwandtner and Markus Klarhoefer and Claudia Lenz and Klaus Scheffler and Rolf-Dieter Stieglitz and Ernst-Wilhelm Radue and Philip McGuire and Anita Riecher-Roessler and Borgwardt, {Stefan J.}",

year = "2012",

doi = "10.1002/hbm.21360",

language = "English",

volume = "33",

pages = "2281--2294",

journal = "HUMAN BRAIN MAPPING",

issn = "1065-9471",

publisher = "Wiley",

number = "10",

}

Smieskova, R, Allen, P, Simon, A, Aston, J, Bendfeldt, K, Drewe, J, Gruber, K, Gschwandtner, U, Klarhoefer, M, Lenz, C, Scheffler, K, Stieglitz, R-D, Radue, E-W, McGuire, P, Riecher-Roessler, A & Borgwardt, SJ 2012, 'Different duration of at-risk mental state associated with neurofunctional abnormalities. A multimodal imaging study', HUMAN BRAIN MAPPING, vol. 33, no. 10, pp. 2281-2294. https://doi.org/10.1002/hbm.21360

TY - JOUR

T1 - Different duration of at-risk mental state associated with neurofunctional abnormalities.

T2 - A multimodal imaging study

AU - Smieskova, Renata

AU - Allen, Paul

AU - Simon, Andor

AU - Aston, Jacqueline

AU - Bendfeldt, Kerstin

AU - Drewe, Juergen

AU - Gruber, Kerstin

AU - Gschwandtner, Ute

AU - Klarhoefer, Markus

AU - Lenz, Claudia

AU - Scheffler, Klaus

AU - Stieglitz, Rolf-Dieter

AU - Radue, Ernst-Wilhelm

AU - McGuire, Philip

AU - Riecher-Roessler, Anita

AU - Borgwardt, Stefan J.

PY - 2012

Y1 - 2012

N2 - Objectives: Neurofunctional alterations are correlates of vulnerability to psychosis, as well as of the disorder itself. How these abnormalities relate to different probabilities for later transition to psychosis is unclear. We investigated vulnerability- versus disease-related versus resilience biomarkers of psychosis during working memory (WM) processing in individuals with an at-risk mental state (ARMS). Experimental design: Patients with first-episode psychosis (FEP, n = 21), short-term ARMS (ARMS-ST, n = 17), long-term ARMS (ARMS-LT, n = 16), and healthy controls (HC, n = 20) were investigated with an n-back WM task. We examined functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) data in conjunction using biological parametric mapping (BPM) toolbox. Principal observations: There were no differences in accuracy, but the FEP and the ARMS-ST group had longer reaction times compared with the HC and the ARMS-LT group. With the 2-back > 0-back contrast, we found reduced functional activation in ARMS-ST and FEP compared with the HC group in parietal and middle frontal regions. Relative to ARMS-LT individuals, FEP patients showed decreased activation in the bilateral inferior frontal gyrus and insula, and in the left prefrontal cortex. Compared with the ARMS-LT, the ARMS-ST subjects showed reduced activation in the right inferior frontal gyrus and insula. Reduced insular and prefrontal activation was associated with gray matter volume reduction in the same area in the ARMS-LT group. Conclusions: These findings suggest that vulnerability to psychosis was associated with neurofunctional alterations in fronto-temporo-parietal networks in a WM task. Neurofunctional differences within the ARMS were related to different duration of the prodromal state and resilience factors. Hum Brain Mapp 33:22812294, 2012. (c) 2011 Wiley Periodicals, Inc.

AB - Objectives: Neurofunctional alterations are correlates of vulnerability to psychosis, as well as of the disorder itself. How these abnormalities relate to different probabilities for later transition to psychosis is unclear. We investigated vulnerability- versus disease-related versus resilience biomarkers of psychosis during working memory (WM) processing in individuals with an at-risk mental state (ARMS). Experimental design: Patients with first-episode psychosis (FEP, n = 21), short-term ARMS (ARMS-ST, n = 17), long-term ARMS (ARMS-LT, n = 16), and healthy controls (HC, n = 20) were investigated with an n-back WM task. We examined functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging (sMRI) data in conjunction using biological parametric mapping (BPM) toolbox. Principal observations: There were no differences in accuracy, but the FEP and the ARMS-ST group had longer reaction times compared with the HC and the ARMS-LT group. With the 2-back > 0-back contrast, we found reduced functional activation in ARMS-ST and FEP compared with the HC group in parietal and middle frontal regions. Relative to ARMS-LT individuals, FEP patients showed decreased activation in the bilateral inferior frontal gyrus and insula, and in the left prefrontal cortex. Compared with the ARMS-LT, the ARMS-ST subjects showed reduced activation in the right inferior frontal gyrus and insula. Reduced insular and prefrontal activation was associated with gray matter volume reduction in the same area in the ARMS-LT group. Conclusions: These findings suggest that vulnerability to psychosis was associated with neurofunctional alterations in fronto-temporo-parietal networks in a WM task. Neurofunctional differences within the ARMS were related to different duration of the prodromal state and resilience factors. Hum Brain Mapp 33:22812294, 2012. (c) 2011 Wiley Periodicals, Inc.

U2 - 10.1002/hbm.21360

DO - 10.1002/hbm.21360

M3 - Article

SN - 1065-9471

VL - 33

SP - 2281

EP - 2294

JO - HUMAN BRAIN MAPPING

JF - HUMAN BRAIN MAPPING

IS - 10

ER -