Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal

Kevin C Maki; Glenn R Gibson; Robin S Dickmann; Cyril W C Kendall; C-Y Oliver Chen; Adele Costabile; Elena M Comelli; Diane L McKay; Nelson G Almeida; David Jenkins; Gordon A Zello; Jeffrey B Blumberg

doi:10.1016/j.nut.2012.02.010

Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal

Kevin C Maki, Glenn R Gibson, Robin S Dickmann, Cyril W C Kendall, C-Y Oliver Chen, Adele Costabile, Elena M Comelli, Diane L McKay, Nelson G Almeida, David Jenkins, Gordon A Zello, Jeffrey B Blumberg

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: We assessed whether a wheat bran extract containing arabino-xylan-oligosaccharide (AXOS) elicited a prebiotic effect and influenced other physiologic parameters when consumed in ready-to-eat cereal at two dose levels.

METHODS: This double-blind, randomized, controlled, crossover trial evaluated the effects of consuming AXOS at 0 (control), 2.2, or 4.8 g/d as part of ready-to-eat cereal for 3 wk in 55 healthy men and women. Fecal microbial levels, postprandial serum ferulic acid concentrations, and other physiologic parameters were assessed at the beginning and end of each condition.

RESULTS: The median bifidobacteria content of stool samples (log₁₀/grams of dry weight [DW]) was found to be higher in the subjects consuming the 4.8-g/d dose (10.03) than in those consuming 2.2 g/d (9.93) and control (9.84, P < 0.001). No significant changes in the populations of other fecal microbes were observed, indicating a selective increase in fecal bifidobacteria. Postprandial ferulic acid was measured at 120 min at the start and end of each 3-wk treatment period in subjects at least 50 y old (n = 37) and increased in a dose-dependent manner (end-of-treatment values 0.007, 0.050, and 0.069 μg/mL for the control, AXOS 2.2 g/d, and AXOS 4.8 g/d conditions, respectively, P for trend < 0.001).

CONCLUSION: These results indicate that AXOS has prebiotic properties, selectively increasing fecal bifidobacteria, and increases postprandial ferulic acid concentrations in a dose-dependent manner in healthy men and women.

Original language	English
Pages (from-to)	1115-21
Number of pages	7
Journal	Complete Nutrition
Volume	28
Issue number	11-12
DOIs	https://doi.org/10.1016/j.nut.2012.02.010
Publication status	Published - 10 Jul 2012

Keywords

Adult
Aged
Bifidobacterium
Breakfast
Cohort Studies
Coumaric Acids
Cross-Over Studies
Dietary Fiber
Digestion
Double-Blind Method
Edible Grain
Feces
Female
Food, Fortified
Humans
Illinois
Male
Middle Aged
Oligosaccharides
Plant Extracts
Triticum
Xylans

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10.1016/j.nut.2012.02.010

Cite this

Maki, K. C., Gibson, G. R., Dickmann, R. S., Kendall, C. W. C., Chen, C.-Y. O., Costabile, A., Comelli, E. M., McKay, D. L., Almeida, N. G., Jenkins, D., Zello, G. A., & Blumberg, J. B. (2012). Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal. Complete Nutrition , 28(11-12), 1115-21. https://doi.org/10.1016/j.nut.2012.02.010

@article{3f8e87e4b693432a963844e2e6d595f6,

title = "Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal",

abstract = "OBJECTIVE: We assessed whether a wheat bran extract containing arabino-xylan-oligosaccharide (AXOS) elicited a prebiotic effect and influenced other physiologic parameters when consumed in ready-to-eat cereal at two dose levels.METHODS: This double-blind, randomized, controlled, crossover trial evaluated the effects of consuming AXOS at 0 (control), 2.2, or 4.8 g/d as part of ready-to-eat cereal for 3 wk in 55 healthy men and women. Fecal microbial levels, postprandial serum ferulic acid concentrations, and other physiologic parameters were assessed at the beginning and end of each condition.RESULTS: The median bifidobacteria content of stool samples (log₁₀/grams of dry weight [DW]) was found to be higher in the subjects consuming the 4.8-g/d dose (10.03) than in those consuming 2.2 g/d (9.93) and control (9.84, P < 0.001). No significant changes in the populations of other fecal microbes were observed, indicating a selective increase in fecal bifidobacteria. Postprandial ferulic acid was measured at 120 min at the start and end of each 3-wk treatment period in subjects at least 50 y old (n = 37) and increased in a dose-dependent manner (end-of-treatment values 0.007, 0.050, and 0.069 μg/mL for the control, AXOS 2.2 g/d, and AXOS 4.8 g/d conditions, respectively, P for trend < 0.001).CONCLUSION: These results indicate that AXOS has prebiotic properties, selectively increasing fecal bifidobacteria, and increases postprandial ferulic acid concentrations in a dose-dependent manner in healthy men and women.",

keywords = "Adult, Aged, Bifidobacterium, Breakfast, Cohort Studies, Coumaric Acids, Cross-Over Studies, Dietary Fiber, Digestion, Double-Blind Method, Edible Grain, Feces, Female, Food, Fortified, Humans, Illinois, Male, Middle Aged, Oligosaccharides, Plant Extracts, Triticum, Xylans",

author = "Maki, \{Kevin C\} and Gibson, \{Glenn R\} and Dickmann, \{Robin S\} and Kendall, \{Cyril W C\} and Chen, \{C-Y Oliver\} and Adele Costabile and Comelli, \{Elena M\} and McKay, \{Diane L\} and Almeida, \{Nelson G\} and David Jenkins and Zello, \{Gordon A\} and Blumberg, \{Jeffrey B\}",

year = "2012",

month = jul,

day = "10",

doi = "10.1016/j.nut.2012.02.010",

language = "English",

volume = "28",

pages = "1115--21",

journal = "Complete Nutrition ",

publisher = "Complete Media \& Marketing",

number = "11-12",

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TY - JOUR

T1 - Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal

AU - Maki, Kevin C

AU - Gibson, Glenn R

AU - Dickmann, Robin S

AU - Kendall, Cyril W C

AU - Chen, C-Y Oliver

AU - Costabile, Adele

AU - Comelli, Elena M

AU - McKay, Diane L

AU - Almeida, Nelson G

AU - Jenkins, David

AU - Zello, Gordon A

AU - Blumberg, Jeffrey B

PY - 2012/7/10

Y1 - 2012/7/10

N2 - OBJECTIVE: We assessed whether a wheat bran extract containing arabino-xylan-oligosaccharide (AXOS) elicited a prebiotic effect and influenced other physiologic parameters when consumed in ready-to-eat cereal at two dose levels.METHODS: This double-blind, randomized, controlled, crossover trial evaluated the effects of consuming AXOS at 0 (control), 2.2, or 4.8 g/d as part of ready-to-eat cereal for 3 wk in 55 healthy men and women. Fecal microbial levels, postprandial serum ferulic acid concentrations, and other physiologic parameters were assessed at the beginning and end of each condition.RESULTS: The median bifidobacteria content of stool samples (log₁₀/grams of dry weight [DW]) was found to be higher in the subjects consuming the 4.8-g/d dose (10.03) than in those consuming 2.2 g/d (9.93) and control (9.84, P < 0.001). No significant changes in the populations of other fecal microbes were observed, indicating a selective increase in fecal bifidobacteria. Postprandial ferulic acid was measured at 120 min at the start and end of each 3-wk treatment period in subjects at least 50 y old (n = 37) and increased in a dose-dependent manner (end-of-treatment values 0.007, 0.050, and 0.069 μg/mL for the control, AXOS 2.2 g/d, and AXOS 4.8 g/d conditions, respectively, P for trend < 0.001).CONCLUSION: These results indicate that AXOS has prebiotic properties, selectively increasing fecal bifidobacteria, and increases postprandial ferulic acid concentrations in a dose-dependent manner in healthy men and women.

AB - OBJECTIVE: We assessed whether a wheat bran extract containing arabino-xylan-oligosaccharide (AXOS) elicited a prebiotic effect and influenced other physiologic parameters when consumed in ready-to-eat cereal at two dose levels.METHODS: This double-blind, randomized, controlled, crossover trial evaluated the effects of consuming AXOS at 0 (control), 2.2, or 4.8 g/d as part of ready-to-eat cereal for 3 wk in 55 healthy men and women. Fecal microbial levels, postprandial serum ferulic acid concentrations, and other physiologic parameters were assessed at the beginning and end of each condition.RESULTS: The median bifidobacteria content of stool samples (log₁₀/grams of dry weight [DW]) was found to be higher in the subjects consuming the 4.8-g/d dose (10.03) than in those consuming 2.2 g/d (9.93) and control (9.84, P < 0.001). No significant changes in the populations of other fecal microbes were observed, indicating a selective increase in fecal bifidobacteria. Postprandial ferulic acid was measured at 120 min at the start and end of each 3-wk treatment period in subjects at least 50 y old (n = 37) and increased in a dose-dependent manner (end-of-treatment values 0.007, 0.050, and 0.069 μg/mL for the control, AXOS 2.2 g/d, and AXOS 4.8 g/d conditions, respectively, P for trend < 0.001).CONCLUSION: These results indicate that AXOS has prebiotic properties, selectively increasing fecal bifidobacteria, and increases postprandial ferulic acid concentrations in a dose-dependent manner in healthy men and women.

KW - Adult

KW - Aged

KW - Bifidobacterium

KW - Breakfast

KW - Cohort Studies

KW - Coumaric Acids

KW - Cross-Over Studies

KW - Dietary Fiber

KW - Digestion

KW - Double-Blind Method

KW - Edible Grain

KW - Feces

KW - Female

KW - Food, Fortified

KW - Humans

KW - Illinois

KW - Male

KW - Middle Aged

KW - Oligosaccharides

KW - Plant Extracts

KW - Triticum

KW - Xylans

U2 - 10.1016/j.nut.2012.02.010

DO - 10.1016/j.nut.2012.02.010

M3 - Article

C2 - 22771050

VL - 28

SP - 1115

EP - 1121

JO - Complete Nutrition

JF - Complete Nutrition

IS - 11-12

ER -