Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes

Oana Ancu, Jane Naufahu, Richie Barclay, Peter Watt, Richard W. A. Mackenzie

Research output: Contribution to journalArticlepeer-review

103 Downloads (Pure)


The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c; 6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glu- cose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell func- tion, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally, insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion, acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes.
Original languageEnglish
Pages (from-to)55-61
JournalClinical Diabetes and Research
Issue number1
Publication statusPublished - 6 Feb 2021

Cite this