Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes

Oana Ancu; Jane Naufahu; Richie Barclay; Peter Watt; Richard W. A. Mackenzie

Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes

Oana Ancu, Jane Naufahu, Richie Barclay, Peter Watt, Richard W. A. Mackenzie

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Abstract

The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c; 6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glu- cose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell func- tion, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally, insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion, acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes.

Original language	English
Pages (from-to)	55-61
Journal	Clinical Diabetes and Research
Volume	5
Issue number	1
Publication status	Published - 6 Feb 2021

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Cite this

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title = "Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes",

abstract = "The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c; 6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glu- cose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell func- tion, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally, insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion, acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes.",

author = "Oana Ancu and Jane Naufahu and Richie Barclay and Peter Watt and Mackenzie, {Richard W. A.}",

year = "2021",

month = feb,

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language = "English",

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pages = "55--61",

journal = "Clinical Diabetes and Research ",

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TY - JOUR

T1 - Disposition Index (DI) is not Improved with High-Intensity Intermittent Exercise in Adults with Hyperinsulinemia and Pre-Diabetes

AU - Ancu, Oana

AU - Naufahu, Jane

AU - Barclay, Richie

AU - Watt, Peter

AU - Mackenzie, Richard W. A.

PY - 2021/2/6

Y1 - 2021/2/6

N2 - The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c; 6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glu- cose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell func- tion, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally, insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion, acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes.

AB - The progression from pre-diabetes to overt type 2 diabetes is largely attributed to β-cell dysfunction and reduced insulin responsiveness. Exercise improves β-cell function in type 2 diabetics, however in pre-diabetic populations there is no data to support a similar response to acute high intensity exercise. Nine individuals diagnosed with prediabetes [HbA1c; 6.1 (0.2)%)] underwent a resting control, a continuous exercise and a high-intensity exercise trial. A labeled ([6,62H2] glu- cose) intravenous glucose tolerance test (IVGTT) was administered immediately after each trial to calculate β-cell func- tion, 1st [acute (AIRg)] and 2nd phase insulin response to intravenous glucose and disposition index (DI). Data modelling indicated AIRg (P = 0.68) and 2nd phase insulin responsiveness (P = 0.294) were not different between trials. Additionally, insulin response in relation to insulin action (DI) was not statistically different between trials (P = 0.394). In conclusion, acute high intensity exercise does not improve DI and β-cell function in individuals with prediabetes.

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