Does neuroanatomy account for superior temporal dysfunction in early psychosis?: A multimodal MRI investigation

William Petterson-Yeo; Stefania Benetti; Silvia Frisciata; Marco Catani; Steve C.R. Williams; Paul Allen; Philip McGuire; Andrea Mechelli

doi:10.1503/jpn.140082

Does neuroanatomy account for superior temporal dysfunction in early psychosis? A multimodal MRI investigation

William Petterson-Yeo, Stefania Benetti, Silvia Frisciata, Marco Catani, Steve C.R. Williams, Paul Allen, Philip McGuire, Andrea Mechelli

Research output: Contribution to journal › Article

Abstract

Background: Neuroimaging studies of ultra-high risk (UHR) and first-episode psychosis (FEP) have revealed widespread alterations in brain structure and function. Recent evidence suggests there is an intrinsic relationship between these 2 types of alterations; however, there is very little research linking these 2 modalities in the early stages of psychosis. Methods: To test the hypothesis that functional alteration in UHR and FEP participants would be associated with corresponding structural alteration, we examined brain function and structure in these participants as well as in a group of healthy controls using multimodal MRI. The data were analyzed using statistical parametric mapping. Results: We included 24 participants in the FEP group, 18 in the UHR group and 21 in the control group. Patients in the FEP group showed a reduction in functional activation in the left superior temporal gyrus relative to controls, and the UHR group showed intermediate values. The same region showed a corresponding reduction in grey matter volume in the FEP group relative to controls. However, while the difference in grey matter volume remained significant after including functional activation as a covariate of no interest, the reduction in functional activation was no longer evident after including grey matter volume as a covariate of no interest. Limitations: Our sample size was relatively small. All participants in the FEP group and 2 in the UHR group had received antipsychotic medication, which may have impacted neurofunction and/or neuroanatomy. Conclusion: Our results suggest that superior temporal dysfunction in early psychosis is accounted for by a corresponding alteration in grey matter volume. This finding has important implications for the interpretation of functional alteration in early psychosis.

Original language	English
Pages (from-to)	100-107
Journal	JOURNAL OF PSYCHIATRY & NEUROSCIENCE
Volume	40
Issue number	2
DOIs	https://doi.org/10.1503/jpn.140082
Publication status	Published - 2015

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10.1503/jpn.140082

http://dx.doi.org/10.1503/jpn.140082

Cite this

@article{f4636cc3b47e45ba8186dd4437bcecc4,

title = "Does neuroanatomy account for superior temporal dysfunction in early psychosis?: A multimodal MRI investigation",

abstract = "Background: Neuroimaging studies of ultra-high risk (UHR) and first-episode psychosis (FEP) have revealed widespread alterations in brain structure and function. Recent evidence suggests there is an intrinsic relationship between these 2 types of alterations; however, there is very little research linking these 2 modalities in the early stages of psychosis. Methods: To test the hypothesis that functional alteration in UHR and FEP participants would be associated with corresponding structural alteration, we examined brain function and structure in these participants as well as in a group of healthy controls using multimodal MRI. The data were analyzed using statistical parametric mapping. Results: We included 24 participants in the FEP group, 18 in the UHR group and 21 in the control group. Patients in the FEP group showed a reduction in functional activation in the left superior temporal gyrus relative to controls, and the UHR group showed intermediate values. The same region showed a corresponding reduction in grey matter volume in the FEP group relative to controls. However, while the difference in grey matter volume remained significant after including functional activation as a covariate of no interest, the reduction in functional activation was no longer evident after including grey matter volume as a covariate of no interest. Limitations: Our sample size was relatively small. All participants in the FEP group and 2 in the UHR group had received antipsychotic medication, which may have impacted neurofunction and/or neuroanatomy. Conclusion: Our results suggest that superior temporal dysfunction in early psychosis is accounted for by a corresponding alteration in grey matter volume. This finding has important implications for the interpretation of functional alteration in early psychosis.",

author = "William Petterson-Yeo and Stefania Benetti and Silvia Frisciata and Marco Catani and Williams, {Steve C.R.} and Paul Allen and Philip McGuire and Andrea Mechelli",

year = "2015",

doi = "10.1503/jpn.140082",

language = "English",

volume = "40",

pages = "100--107",

journal = "JOURNAL OF PSYCHIATRY & NEUROSCIENCE",

issn = "1180-4882",

publisher = "Canadian Medical Association",

number = "2",

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TY - JOUR

T1 - Does neuroanatomy account for superior temporal dysfunction in early psychosis?

T2 - A multimodal MRI investigation

AU - Petterson-Yeo, William

AU - Benetti, Stefania

AU - Frisciata, Silvia

AU - Catani, Marco

AU - Williams, Steve C.R.

AU - Allen, Paul

AU - McGuire, Philip

AU - Mechelli, Andrea

PY - 2015

Y1 - 2015

N2 - Background: Neuroimaging studies of ultra-high risk (UHR) and first-episode psychosis (FEP) have revealed widespread alterations in brain structure and function. Recent evidence suggests there is an intrinsic relationship between these 2 types of alterations; however, there is very little research linking these 2 modalities in the early stages of psychosis. Methods: To test the hypothesis that functional alteration in UHR and FEP participants would be associated with corresponding structural alteration, we examined brain function and structure in these participants as well as in a group of healthy controls using multimodal MRI. The data were analyzed using statistical parametric mapping. Results: We included 24 participants in the FEP group, 18 in the UHR group and 21 in the control group. Patients in the FEP group showed a reduction in functional activation in the left superior temporal gyrus relative to controls, and the UHR group showed intermediate values. The same region showed a corresponding reduction in grey matter volume in the FEP group relative to controls. However, while the difference in grey matter volume remained significant after including functional activation as a covariate of no interest, the reduction in functional activation was no longer evident after including grey matter volume as a covariate of no interest. Limitations: Our sample size was relatively small. All participants in the FEP group and 2 in the UHR group had received antipsychotic medication, which may have impacted neurofunction and/or neuroanatomy. Conclusion: Our results suggest that superior temporal dysfunction in early psychosis is accounted for by a corresponding alteration in grey matter volume. This finding has important implications for the interpretation of functional alteration in early psychosis.

AB - Background: Neuroimaging studies of ultra-high risk (UHR) and first-episode psychosis (FEP) have revealed widespread alterations in brain structure and function. Recent evidence suggests there is an intrinsic relationship between these 2 types of alterations; however, there is very little research linking these 2 modalities in the early stages of psychosis. Methods: To test the hypothesis that functional alteration in UHR and FEP participants would be associated with corresponding structural alteration, we examined brain function and structure in these participants as well as in a group of healthy controls using multimodal MRI. The data were analyzed using statistical parametric mapping. Results: We included 24 participants in the FEP group, 18 in the UHR group and 21 in the control group. Patients in the FEP group showed a reduction in functional activation in the left superior temporal gyrus relative to controls, and the UHR group showed intermediate values. The same region showed a corresponding reduction in grey matter volume in the FEP group relative to controls. However, while the difference in grey matter volume remained significant after including functional activation as a covariate of no interest, the reduction in functional activation was no longer evident after including grey matter volume as a covariate of no interest. Limitations: Our sample size was relatively small. All participants in the FEP group and 2 in the UHR group had received antipsychotic medication, which may have impacted neurofunction and/or neuroanatomy. Conclusion: Our results suggest that superior temporal dysfunction in early psychosis is accounted for by a corresponding alteration in grey matter volume. This finding has important implications for the interpretation of functional alteration in early psychosis.

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DO - 10.1503/jpn.140082

M3 - Article

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