Dysconnectivity in schizophrenia:: Where are we now?

Wiliam Petterson-Yeo; Paul Allen; Stefania Benetti; Philip McGuire; Andrea Mechelli

doi:10.1016/j.neubiorev.2010.11.004

Dysconnectivity in schizophrenia: Where are we now?

Wiliam Petterson-Yeo, Paul Allen, Stefania Benetti, Philip McGuire, Andrea Mechelli

Research output: Contribution to journal › Article

Abstract

The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of functional and structural neuroimaging studies have been conducted to investigate this hypothesis, across the full course of the disorder; from people at Ultra-High-Risk of developing psychosis to patients with chronic SZ. However the results of these studies have not always been consistent, and to date, there have been no attempts to summarise the results of both methodologies in conjunction. In this article, we systematically review both the structural and functional connectivity literature in SZ. The main trends to emerge are that schizophrenia is associated with connectivity reductions, as opposed to increases, relative to healthy controls, and that this is particularly evident in the connections involving the frontal lobe. These two trends appear to apply across all stages of the disorder, and to be independent of the neuroimaging methodology employed. We discuss the potential implications of these trends, and identify possible future investigative directions. (C) 2010 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1110-1124
Journal	Neuroscience & Biobehavioral Reviews
Volume	35
Issue number	5
DOIs	https://doi.org/10.1016/j.neubiorev.2010.11.004
Publication status	Published - 2011

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10.1016/j.neubiorev.2010.11.004

http://dx.doi.org/10.1016/j.neubiorev.2010.11.004

Cite this

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title = "Dysconnectivity in schizophrenia:: Where are we now?",

abstract = "The disconnection hypothesis suggests that the core symptoms of schizophrenia (SZ) are related to aberrant, or 'dys-', connectivity between distinct brain regions. A proliferation of functional and structural neuroimaging studies have been conducted to investigate this hypothesis, across the full course of the disorder; from people at Ultra-High-Risk of developing psychosis to patients with chronic SZ. However the results of these studies have not always been consistent, and to date, there have been no attempts to summarise the results of both methodologies in conjunction. In this article, we systematically review both the structural and functional connectivity literature in SZ. The main trends to emerge are that schizophrenia is associated with connectivity reductions, as opposed to increases, relative to healthy controls, and that this is particularly evident in the connections involving the frontal lobe. These two trends appear to apply across all stages of the disorder, and to be independent of the neuroimaging methodology employed. We discuss the potential implications of these trends, and identify possible future investigative directions. (C) 2010 Elsevier Ltd. All rights reserved.",

author = "Wiliam Petterson-Yeo and Paul Allen and Stefania Benetti and Philip McGuire and Andrea Mechelli",

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AU - Petterson-Yeo, Wiliam

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