Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells

Moises Garcia-Arencibia; Eduardo Molina-Holgado; Francisco Molina-Holgado

doi:10.1111/bph.14369

Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells

Moises Garcia-Arencibia, Eduardo Molina-Holgado, Francisco Molina-Holgado

School of Life and Health Sciences

Research output: Contribution to journal › Book/Film/Article review › peer-review

Abstract

Cell fate events are regulated by different endogenous developmental factors such as the cell micro-environment, external or remote signals and epigenetic factors. Among the many regulatory factors, endocannabinoid-associated signalling pathways are known to conduct several of these events in the developing nervous system and in the adult brain. Interestingly, endocannabinoids exert modulatory actions in both physiological and pathological conditions. Endocannabinoid signalling can promote cell survival by acting on non-transformed brain cells (neurons, astrocytes or oligodendrocytes) and can have either a protumoural or antitumoural effect on transformed cells. Moreover, endocannabinoids are able to attenuate the detrimental effects on neurogenesis and neuroinflammation associated with ageing. Thus, the endocannabinoid system emerges as an important regulator of cell fate, controlling cell survival/cell death decisions depending on the cell type and its environment.

Original language	English
Journal	British Journal of Pharmacology
DOIs	https://doi.org/10.1111/bph.14369
Publication status	Published - 24 May 2018

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10.1111/bph.14369

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title = "Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells",

abstract = "Cell fate events are regulated by different endogenous developmental factors such as the cell micro-environment, external or remote signals and epigenetic factors. Among the many regulatory factors, endocannabinoid-associated signalling pathways are known to conduct several of these events in the developing nervous system and in the adult brain. Interestingly, endocannabinoids exert modulatory actions in both physiological and pathological conditions. Endocannabinoid signalling can promote cell survival by acting on non-transformed brain cells (neurons, astrocytes or oligodendrocytes) and can have either a protumoural or antitumoural effect on transformed cells. Moreover, endocannabinoids are able to attenuate the detrimental effects on neurogenesis and neuroinflammation associated with ageing. Thus, the endocannabinoid system emerges as an important regulator of cell fate, controlling cell survival/cell death decisions depending on the cell type and its environment.",

author = "Moises Garcia-Arencibia and Eduardo Molina-Holgado and Francisco Molina-Holgado",

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T1 - Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells

AU - Garcia-Arencibia, Moises

AU - Molina-Holgado, Eduardo

AU - Molina-Holgado, Francisco

PY - 2018/5/24

Y1 - 2018/5/24

N2 - Cell fate events are regulated by different endogenous developmental factors such as the cell micro-environment, external or remote signals and epigenetic factors. Among the many regulatory factors, endocannabinoid-associated signalling pathways are known to conduct several of these events in the developing nervous system and in the adult brain. Interestingly, endocannabinoids exert modulatory actions in both physiological and pathological conditions. Endocannabinoid signalling can promote cell survival by acting on non-transformed brain cells (neurons, astrocytes or oligodendrocytes) and can have either a protumoural or antitumoural effect on transformed cells. Moreover, endocannabinoids are able to attenuate the detrimental effects on neurogenesis and neuroinflammation associated with ageing. Thus, the endocannabinoid system emerges as an important regulator of cell fate, controlling cell survival/cell death decisions depending on the cell type and its environment.

AB - Cell fate events are regulated by different endogenous developmental factors such as the cell micro-environment, external or remote signals and epigenetic factors. Among the many regulatory factors, endocannabinoid-associated signalling pathways are known to conduct several of these events in the developing nervous system and in the adult brain. Interestingly, endocannabinoids exert modulatory actions in both physiological and pathological conditions. Endocannabinoid signalling can promote cell survival by acting on non-transformed brain cells (neurons, astrocytes or oligodendrocytes) and can have either a protumoural or antitumoural effect on transformed cells. Moreover, endocannabinoids are able to attenuate the detrimental effects on neurogenesis and neuroinflammation associated with ageing. Thus, the endocannabinoid system emerges as an important regulator of cell fate, controlling cell survival/cell death decisions depending on the cell type and its environment.

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DO - 10.1111/bph.14369

M3 - Book/Film/Article review

SN - 1476-5381

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

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