Abstract
Using proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an after-effect of episodes of illness or its treatment. We sought to examine this question by examining a group of high-risk, never-depressed, individuals. We used MRS to measure GABA and glutamate in parieto-occipital cortex in young people (ages 16-21 yr) with a family history of parental depression (n=24) but no personal history of illness and a control group without a history of depression in any first-degree relative (n=28). Participants with a parental history of depression had significantly higher levels of glutamate than controls in parieto-occipital cortex (F₁,₄₇=5.5, p=0.02). These findings suggest that abnormalities in glutamate neurotransmission may reflect a trait marker of vulnerability to depression.
| Original language | English |
|---|---|
| Pages (from-to) | 255-9 |
| Number of pages | 5 |
| Journal | International Journal of Neuropsychopharmacology |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2011 |
Keywords
- Adolescent
- Cerebral Cortex
- Depression
- Depressive Disorder
- Depressive Disorder, Major
- Family
- Female
- Glutamic Acid
- Glutamine
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Occipital Lobe
- Risk Factors
- Young Adult
- gamma-Aminobutyric Acid