Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis:: A combined voxel-based morphometry and voxel-based cortical thickness study

Stefania Benetti; William Petterson-Yeo; Chloe Hutton; Marco Catani; Steve C.R. Williams; Paul Allen; Lana M. Kambeitz-Ilankovic; Philip McGuire; Andrea Mechelli

doi:10.1016/j.schres.2013.08.030

Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study

Stefania Benetti, William Petterson-Yeo, Chloe Hutton, Marco Catani, Steve C.R. Williams, Paul Allen, Lana M. Kambeitz-Ilankovic, Philip McGuire, Andrea Mechelli

Research output: Contribution to journal › Article

Abstract

Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology. (C) 2013 The Authors. Published by Elsevier B. V. All rights reserved.

Original language	English
Pages (from-to)	505-511
Journal	SCHIZOPHRENIA RESEARCH
Volume	150
DOIs	https://doi.org/10.1016/j.schres.2013.08.030
Publication status	Published - 2013

Access to Document

10.1016/j.schres.2013.08.030

http://dx.doi.org/10.1016/j.schres.2013.08.030

Cite this

Benetti, S., Petterson-Yeo, W., Hutton, C., Catani, M., Williams, S. C. R., Allen, P., Kambeitz-Ilankovic, L. M., McGuire, P., & Mechelli, A. (2013). Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study. SCHIZOPHRENIA RESEARCH, 150, 505-511. https://doi.org/10.1016/j.schres.2013.08.030

@article{8aebb283131a41089d2cc22a54c01566,

title = "Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis:: A combined voxel-based morphometry and voxel-based cortical thickness study",

abstract = "Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology. (C) 2013 The Authors. Published by Elsevier B. V. All rights reserved.",

author = "Stefania Benetti and William Petterson-Yeo and Chloe Hutton and Marco Catani and Williams, {Steve C.R.} and Paul Allen and Kambeitz-Ilankovic, {Lana M.} and Philip McGuire and Andrea Mechelli",

year = "2013",

doi = "10.1016/j.schres.2013.08.030",

language = "English",

volume = "150",

pages = "505--511",

journal = "SCHIZOPHRENIA RESEARCH",

issn = "0920-9964",

publisher = "Elsevier",

}

Benetti, S, Petterson-Yeo, W, Hutton, C, Catani, M, Williams, SCR, Allen, P, Kambeitz-Ilankovic, LM, McGuire, P & Mechelli, A 2013, 'Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis: A combined voxel-based morphometry and voxel-based cortical thickness study', SCHIZOPHRENIA RESEARCH, vol. 150, pp. 505-511. https://doi.org/10.1016/j.schres.2013.08.030

TY - JOUR

T1 - Elucidating neuroanatomical alterations in the at risk mental state and first episode psychosis:

T2 - A combined voxel-based morphometry and voxel-based cortical thickness study

AU - Benetti, Stefania

AU - Petterson-Yeo, William

AU - Hutton, Chloe

AU - Catani, Marco

AU - Williams, Steve C.R.

AU - Allen, Paul

AU - Kambeitz-Ilankovic, Lana M.

AU - McGuire, Philip

AU - Mechelli, Andrea

PY - 2013

Y1 - 2013

N2 - Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology. (C) 2013 The Authors. Published by Elsevier B. V. All rights reserved.

AB - Previous studies have reported alterations in grey matter volume and cortical thickness in individuals at high risk of developing psychosis and patients in the early stages of the disorder. Because these studies have typically focused on either grey matter volume or cortical thickness separately, the relationship between these two types of alterations is currently unclear. In the present investigation we used both voxel-based cortical thickness (VBCT) and voxel-based morphometry (VBM) to examine neuroanatomical differences in 21 individuals with an At Risk Mental State (ARMS) for psychosis, 26 patients with a First Episode of Psychosis (FEP) and 24 healthy controls. Statistical inferences were made at P < 0.05 after correction for multiple comparisons. Cortical thinning in the right superior temporal gyrus was observed in both individuals at high risk of developing psychosis and patients with a first episode of the disorder, and therefore is likely to represent a marker of vulnerability. In contrast, the right posterior cingulate cortex showed cortical thinning in FEP patients relative to individuals at high risk, and therefore appears to be implicated in the onset of the disease. These neuroanatomical differences were expressed in terms of cortical thickness but not in terms of grey matter volume, and therefore may reflect specific cortical atrophy as opposed to variations in sulcal and gyral morphology. (C) 2013 The Authors. Published by Elsevier B. V. All rights reserved.

U2 - 10.1016/j.schres.2013.08.030

DO - 10.1016/j.schres.2013.08.030

M3 - Article

SN - 0920-9964

VL - 150

SP - 505

EP - 511

JO - SCHIZOPHRENIA RESEARCH

JF - SCHIZOPHRENIA RESEARCH

ER -