Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men

Meera Ladwa; Oluwatoyosi Bello; Olah Hakim; Fariba Shojaee-Moradie; Maria Linda Boselli; Geoff Charles-Edwards; Janet Peacock; A Margot Umpleby; Stephanie A Amiel; Riccardo C Bonadonna; Louise M Goff

Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men

Meera Ladwa, Oluwatoyosi Bello, Olah Hakim, Fariba Shojaee-Moradie, Maria Linda Boselli, Geoff Charles-Edwards, Janet Peacock, A Margot Umpleby, Stephanie A Amiel, Riccardo C Bonadonna, Louise M Goff

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations. Therefore, we aimed to compare postprandial insulin secretion and the relationships between insulin secretion, insulin sensitivity and pancreatic fat in men of black West African (BA) and white European (WE) ancestry.

RESEARCH DESIGN AND METHODS: A cross-sectional, observational study in which 23 WE and 23 BA men with normal glucose tolerance, matched for body mass index, underwent a mixed meal tolerance test with C peptide modeling to measure beta cell insulin secretion, an MRI to quantify intrapancreatic lipid (IPL), and a hyperinsulinemic-euglycemic clamp to measure whole-body insulin sensitivity.

RESULTS: Postprandial insulin secretion was lower in BA versus WE men following adjustment for insulin sensitivity (estimated marginal means, BA vs WE: 40.5 (95% CI 31.8 to 49.2) × 103 vs 56.4 (95% CI 48.9 to 63.8) × 103 pmol/m2 body surface area × 180 min, p=0.008). There was a significantly different relationship by ethnicity between IPL and insulin secretion, with a stronger relationship in WE than in BA (r=0.59 vs r=0.39, interaction p=0.036); however, IPL was not a predictor of insulin secretion in either ethnic group following adjustment for insulin sensitivity.

CONCLUSIONS: Ethnicity is an independent determinant of beta cell function in black and white men. In response to a meal, healthy BA men exhibit lower insulin secretion compared with their WE counterparts for their given insulin sensitivity. Ethnic differences in beta cell function may contribute to the greater risk of T2D in populations of African ancestry.

Original language	English
Journal	BMJ open diabetes research & care
Volume	9
Issue number	1
Publication status	Published - 24 Mar 2021

Keywords

African Americans
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Humans
Insulin
Insulin Resistance
Male

Access to Document

https://drc.bmj.com/content/9/1/e002034

Cite this

Ladwa, M., Bello, O., Hakim, O., Shojaee-Moradie, F., Boselli, M. L., Charles-Edwards, G., Peacock, J., Umpleby, A. M., Amiel, S. A., Bonadonna, R. C., & Goff, L. M. (2021). Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men. BMJ open diabetes research & care, 9(1). https://drc.bmj.com/content/9/1/e002034

@article{decf607e440e4b15ae11e0f671f7730e,

title = "Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men",

abstract = "INTRODUCTION: It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations. Therefore, we aimed to compare postprandial insulin secretion and the relationships between insulin secretion, insulin sensitivity and pancreatic fat in men of black West African (BA) and white European (WE) ancestry.RESEARCH DESIGN AND METHODS: A cross-sectional, observational study in which 23 WE and 23 BA men with normal glucose tolerance, matched for body mass index, underwent a mixed meal tolerance test with C peptide modeling to measure beta cell insulin secretion, an MRI to quantify intrapancreatic lipid (IPL), and a hyperinsulinemic-euglycemic clamp to measure whole-body insulin sensitivity.RESULTS: Postprandial insulin secretion was lower in BA versus WE men following adjustment for insulin sensitivity (estimated marginal means, BA vs WE: 40.5 (95% CI 31.8 to 49.2) × 103 vs 56.4 (95% CI 48.9 to 63.8) × 103 pmol/m2 body surface area × 180 min, p=0.008). There was a significantly different relationship by ethnicity between IPL and insulin secretion, with a stronger relationship in WE than in BA (r=0.59 vs r=0.39, interaction p=0.036); however, IPL was not a predictor of insulin secretion in either ethnic group following adjustment for insulin sensitivity.CONCLUSIONS: Ethnicity is an independent determinant of beta cell function in black and white men. In response to a meal, healthy BA men exhibit lower insulin secretion compared with their WE counterparts for their given insulin sensitivity. Ethnic differences in beta cell function may contribute to the greater risk of T2D in populations of African ancestry.",

keywords = "African Americans, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Humans, Insulin, Insulin Resistance, Male",

author = "Meera Ladwa and Oluwatoyosi Bello and Olah Hakim and Fariba Shojaee-Moradie and Boselli, {Maria Linda} and Geoff Charles-Edwards and Janet Peacock and Umpleby, {A Margot} and Amiel, {Stephanie A} and Bonadonna, {Riccardo C} and Goff, {Louise M}",

note = "{\textcopyright} Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2021",

month = mar,

day = "24",

language = "English",

volume = "9",

journal = "BMJ open diabetes research & care",

issn = "2052-4897",

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Ladwa, M, Bello, O, Hakim, O, Shojaee-Moradie, F, Boselli, ML, Charles-Edwards, G, Peacock, J, Umpleby, AM, Amiel, SA, Bonadonna, RC & Goff, LM 2021, 'Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men', BMJ open diabetes research & care, vol. 9, no. 1. <https://drc.bmj.com/content/9/1/e002034>

TY - JOUR

T1 - Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men

AU - Ladwa, Meera

AU - Bello, Oluwatoyosi

AU - Hakim, Olah

AU - Shojaee-Moradie, Fariba

AU - Boselli, Maria Linda

AU - Charles-Edwards, Geoff

AU - Peacock, Janet

AU - Umpleby, A Margot

AU - Amiel, Stephanie A

AU - Bonadonna, Riccardo C

AU - Goff, Louise M

PY - 2021/3/24

Y1 - 2021/3/24

N2 - INTRODUCTION: It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations. Therefore, we aimed to compare postprandial insulin secretion and the relationships between insulin secretion, insulin sensitivity and pancreatic fat in men of black West African (BA) and white European (WE) ancestry.RESEARCH DESIGN AND METHODS: A cross-sectional, observational study in which 23 WE and 23 BA men with normal glucose tolerance, matched for body mass index, underwent a mixed meal tolerance test with C peptide modeling to measure beta cell insulin secretion, an MRI to quantify intrapancreatic lipid (IPL), and a hyperinsulinemic-euglycemic clamp to measure whole-body insulin sensitivity.RESULTS: Postprandial insulin secretion was lower in BA versus WE men following adjustment for insulin sensitivity (estimated marginal means, BA vs WE: 40.5 (95% CI 31.8 to 49.2) × 103 vs 56.4 (95% CI 48.9 to 63.8) × 103 pmol/m2 body surface area × 180 min, p=0.008). There was a significantly different relationship by ethnicity between IPL and insulin secretion, with a stronger relationship in WE than in BA (r=0.59 vs r=0.39, interaction p=0.036); however, IPL was not a predictor of insulin secretion in either ethnic group following adjustment for insulin sensitivity.CONCLUSIONS: Ethnicity is an independent determinant of beta cell function in black and white men. In response to a meal, healthy BA men exhibit lower insulin secretion compared with their WE counterparts for their given insulin sensitivity. Ethnic differences in beta cell function may contribute to the greater risk of T2D in populations of African ancestry.

AB - INTRODUCTION: It is increasingly recognized that type 2 diabetes (T2D) is a heterogenous disease with ethnic variations. Differences in insulin secretion, insulin resistance and ectopic fat are thought to contribute to these variations. Therefore, we aimed to compare postprandial insulin secretion and the relationships between insulin secretion, insulin sensitivity and pancreatic fat in men of black West African (BA) and white European (WE) ancestry.RESEARCH DESIGN AND METHODS: A cross-sectional, observational study in which 23 WE and 23 BA men with normal glucose tolerance, matched for body mass index, underwent a mixed meal tolerance test with C peptide modeling to measure beta cell insulin secretion, an MRI to quantify intrapancreatic lipid (IPL), and a hyperinsulinemic-euglycemic clamp to measure whole-body insulin sensitivity.RESULTS: Postprandial insulin secretion was lower in BA versus WE men following adjustment for insulin sensitivity (estimated marginal means, BA vs WE: 40.5 (95% CI 31.8 to 49.2) × 103 vs 56.4 (95% CI 48.9 to 63.8) × 103 pmol/m2 body surface area × 180 min, p=0.008). There was a significantly different relationship by ethnicity between IPL and insulin secretion, with a stronger relationship in WE than in BA (r=0.59 vs r=0.39, interaction p=0.036); however, IPL was not a predictor of insulin secretion in either ethnic group following adjustment for insulin sensitivity.CONCLUSIONS: Ethnicity is an independent determinant of beta cell function in black and white men. In response to a meal, healthy BA men exhibit lower insulin secretion compared with their WE counterparts for their given insulin sensitivity. Ethnic differences in beta cell function may contribute to the greater risk of T2D in populations of African ancestry.

KW - African Americans

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 2

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Male

M3 - Article

C2 - 33762314

SN - 2052-4897

VL - 9

JO - BMJ open diabetes research & care

JF - BMJ open diabetes research & care

IS - 1

ER -