Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

Andrea G S Buggins, Ana Levi, Satyen Gohil, Keith Fishlock, Piers E M Patten, Yolanda Calle, Deborah Yallop, Stephen Devereux

Research output: Contribution to journalArticlepeer-review


Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.

Original languageEnglish
Pages (from-to)216-22
Number of pages7
JournalBritish Journal of Haematology
Issue number2
Publication statusPublished - Jul 2011


  • Antigens, CD38
  • Antigens, CD44
  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Humans
  • Integrin alpha4
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Macromolecular Substances
  • Matrix Metalloproteinase 9
  • Membrane Glycoproteins
  • Microscopy, Fluorescence
  • Prognosis

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