Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

Andrea G S Buggins; Ana Levi; Satyen Gohil; Keith Fishlock; Piers E M Patten; Yolanda Calle; Deborah Yallop; Stephen Devereux

doi:10.1111/j.1365-2141.2011.08725.x

Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

Andrea G S Buggins, Ana Levi, Satyen Gohil, Keith Fishlock, Piers E M Patten, Yolanda Calle, Deborah Yallop, Stephen Devereux

Research output: Contribution to journal › Article › peer-review

Abstract

Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.

Original language	English
Pages (from-to)	216-22
Number of pages	7
Journal	British Journal of Haematology
Volume	154
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.2011.08725.x
Publication status	Published - Jul 2011

Keywords

Antigens, CD38
Antigens, CD44
Antigens, Neoplasm
Biomarkers, Tumor
Humans
Integrin alpha4
Leukemia, Lymphocytic, Chronic, B-Cell
Macromolecular Substances
Matrix Metalloproteinase 9
Membrane Glycoproteins
Microscopy, Fluorescence
Prognosis

Access to Document

10.1111/j.1365-2141.2011.08725.x

Cite this

@article{b658466e79434249a1866787103fe100,

title = "Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9",

abstract = "Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.",

keywords = "Antigens, CD38, Antigens, CD44, Antigens, Neoplasm, Biomarkers, Tumor, Humans, Integrin alpha4, Leukemia, Lymphocytic, Chronic, B-Cell, Macromolecular Substances, Matrix Metalloproteinase 9, Membrane Glycoproteins, Microscopy, Fluorescence, Prognosis",

author = "Buggins, {Andrea G S} and Ana Levi and Satyen Gohil and Keith Fishlock and Patten, {Piers E M} and Yolanda Calle and Deborah Yallop and Stephen Devereux",

note = "{\textcopyright} 2011 Blackwell Publishing Ltd.",

year = "2011",

month = jul,

doi = "10.1111/j.1365-2141.2011.08725.x",

language = "English",

volume = "154",

pages = "216--22",

journal = "British Journal of Haematology",

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publisher = "Wiley",

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TY - JOUR

T1 - Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9

AU - Buggins, Andrea G S

AU - Levi, Ana

AU - Gohil, Satyen

AU - Fishlock, Keith

AU - Patten, Piers E M

AU - Calle, Yolanda

AU - Yallop, Deborah

AU - Devereux, Stephen

PY - 2011/7

Y1 - 2011/7

N2 - Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.

AB - Progressive chronic lymphocytic leukaemia is characterized by the accumulation of neoplastic B-cells in the tissues and correlates with the expression of prognostic biomarkers, such as CD38, CD49d and matrix metalloproteinase-9 (MMP9), which are involved in migration and tissue invasion. In this study we investigated the physical relationship between these molecules and demonstrated that CD38, CD49d, MMP9 and CD44 were physically associated in a supramolecular cell surface complex. Our findings provide a molecular basis for the correlation between expression of these proteins and prognosis and, as the complex is not present in normal B-cells, suggest a novel leukaemia-specific therapeutic target.

KW - Antigens, CD38

KW - Antigens, CD44

KW - Antigens, Neoplasm

KW - Biomarkers, Tumor

KW - Humans

KW - Integrin alpha4

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Macromolecular Substances

KW - Matrix Metalloproteinase 9

KW - Membrane Glycoproteins

KW - Microscopy, Fluorescence

KW - Prognosis

U2 - 10.1111/j.1365-2141.2011.08725.x

DO - 10.1111/j.1365-2141.2011.08725.x

M3 - Article

C2 - 21569005

SN - 1365-2141

VL - 154

SP - 216

EP - 222

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -