Exploring the effect of chronotype on hippocampal volume and shape: A combined approach.

Charlotte, Mary Horne, Ray Norbury

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Current evidence suggests that acute depression is associated with reduced total hippocampal volume and regional atrophy. Here, using structural magnetic resonance imaging, we assayed linear effects of chronotype on total hippocampal volume and morphology. Later chronotype was associated with localised atrophy in the subiculum region of the right hippocampus in the absence of changes in total volume. The hippocampus forms a key node in a network of brain regions implicated in emotional regulation and alterations in the structure of this region may underpin, in part, the increased vulnerability for depression in late chronotype individuals.
Original languageEnglish
JournalChronobiology International
Early online date5 Apr 2018
Publication statusE-pub ahead of print - 5 Apr 2018

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