Glatiramer acetate attenuates neuropathic allodynia through modulation of adaptive immune cells

Tanya Leger, John Grist, Fulvio D'Acquisto, Anna K Clark, Marzia Malcangio

Research output: Contribution to journalArticlepeer-review


Immune-neuronal interactions contribute to neuropathic pain. Thus, immune-competent cells such as microglia may provide targets for pain relief, as may infiltrating lymphocytes. We evaluated the nature of the lymphocyte response in the spinal cord in association with the maintenance of neuropathic allodynia. We assessed T cell contribution to pain processing by targeting these cells with Glatiramer acetate (GA) which when administered systemically reversed neuropathic allodynia, inhibited microglia response and increased IL-10 and IL-4 expressing T cells in neuropathic dorsal horns. These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention.

Original languageEnglish
Pages (from-to)19-26
Number of pages8
Issue number1-2
Publication statusPublished - May 2011


  • Adaptive Immunity
  • Analysis of Variance
  • Animals
  • CD3 Complex
  • CD4 Antigens
  • Calcium-Binding Proteins
  • Disease Models, Animal
  • Drug Administration Routes
  • Flow Cytometry
  • Glatiramer Acetate
  • Hyperalgesia
  • Immunosuppressive Agents
  • Interleukin-10
  • Interleukin-4
  • Male
  • Microfilament Proteins
  • Microglia
  • Pain Threshold
  • Peptides
  • Rats
  • Rats, Wistar
  • Sciatica
  • Spinal Cord
  • T-Lymphocytes
  • Journal Article
  • Research Support, Non-U.S. Gov't

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