Abstract
Immune-neuronal interactions contribute to neuropathic pain. Thus, immune-competent cells such as microglia may provide targets for pain relief, as may infiltrating lymphocytes. We evaluated the nature of the lymphocyte response in the spinal cord in association with the maintenance of neuropathic allodynia. We assessed T cell contribution to pain processing by targeting these cells with Glatiramer acetate (GA) which when administered systemically reversed neuropathic allodynia, inhibited microglia response and increased IL-10 and IL-4 expressing T cells in neuropathic dorsal horns. These studies advance understanding of lymphocyte contribution to chronic pain and reveal a new mechanism of T cell intervention.
| Original language | English |
|---|---|
| Pages (from-to) | 19-26 |
| Number of pages | 8 |
| Journal | JOURNAL OF NEUROIMMUNOLOGY |
| Volume | 234 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - May 2011 |
Keywords
- Adaptive Immunity
- Analysis of Variance
- Animals
- CD3 Complex
- CD4 Antigens
- Calcium-Binding Proteins
- Disease Models, Animal
- Drug Administration Routes
- Flow Cytometry
- Glatiramer Acetate
- Hyperalgesia
- Immunosuppressive Agents
- Interleukin-10
- Interleukin-4
- Male
- Microfilament Proteins
- Microglia
- Pain Threshold
- Peptides
- Rats
- Rats, Wistar
- Sciatica
- Spinal Cord
- T-Lymphocytes
- Journal Article
- Research Support, Non-U.S. Gov't