Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Jonathan Swann; Yulan Wang; Leticia Abecia; Adele Costabile; Kieran Tuohy; Glenn Gibson; David Roberts; James Sidaway; Huw Jones; Ian D Wilson; Jeremy Nicholson; Elaine Holmes

doi:10.1039/b811468d

Gut microbiome modulates the toxicity of hydrazine: a metabonomic study

Jonathan Swann
, Yulan Wang
, Leticia Abecia
, Adele Costabile
, Kieran Tuohy
, Glenn Gibson
, David Roberts
, James Sidaway
, Huw Jones
, Ian D Wilson
, Jeremy Nicholson
, Elaine Holmes

Research output: Contribution to journal › Article › peer-review

Abstract

The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

Original language	English
Pages (from-to)	351-5
Number of pages	5
Journal	MOLECULAR BIOSYSTEMS
Volume	5
Issue number	4
DOIs	https://doi.org/10.1039/b811468d
Publication status	Published - Apr 2009

Keywords

Animals
Carcinogens
Gastrointestinal Tract
Hydrazines
Magnetic Resonance Spectroscopy
Metabolomics
Metagenome
Rats
Rats, Sprague-Dawley

Access to Document

10.1039/b811468d

Cite this

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title = "Gut microbiome modulates the toxicity of hydrazine: a metabonomic study",

abstract = "The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.",

keywords = "Animals, Carcinogens, Gastrointestinal Tract, Hydrazines, Magnetic Resonance Spectroscopy, Metabolomics, Metagenome, Rats, Rats, Sprague-Dawley",

author = "Jonathan Swann and Yulan Wang and Leticia Abecia and Adele Costabile and Kieran Tuohy and Glenn Gibson and David Roberts and James Sidaway and Huw Jones and Wilson, \{Ian D\} and Jeremy Nicholson and Elaine Holmes",

year = "2009",

month = apr,

doi = "10.1039/b811468d",

language = "English",

volume = "5",

pages = "351--5",

journal = "MOLECULAR BIOSYSTEMS",

issn = "1742-206X",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Gut microbiome modulates the toxicity of hydrazine

T2 - a metabonomic study

AU - Swann, Jonathan

AU - Wang, Yulan

AU - Abecia, Leticia

AU - Costabile, Adele

AU - Tuohy, Kieran

AU - Gibson, Glenn

AU - Roberts, David

AU - Sidaway, James

AU - Jones, Huw

AU - Wilson, Ian D

AU - Nicholson, Jeremy

AU - Holmes, Elaine

PY - 2009/4

Y1 - 2009/4

N2 - The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

AB - The influence of gut microbiota on the toxicity and metabolism of hydrazine has been investigated in germ-free and 'conventional' Sprague Dawley rats using 1H NMR based metabonomic analysis of urine and plasma. Toxicity was more severe in germ-free rats compared with conventional rats for equivalent exposures indicating that bacterial presence altered the nature or extent of response to hydrazine and that the toxic response can vary markedly in the absence of a functional microbiome.

KW - Animals

KW - Carcinogens

KW - Gastrointestinal Tract

KW - Hydrazines

KW - Magnetic Resonance Spectroscopy

KW - Metabolomics

KW - Metagenome

KW - Rats

KW - Rats, Sprague-Dawley

U2 - 10.1039/b811468d

DO - 10.1039/b811468d

M3 - Article

C2 - 19396371

SN - 1742-206X

VL - 5

SP - 351

EP - 355

JO - MOLECULAR BIOSYSTEMS

JF - MOLECULAR BIOSYSTEMS

IS - 4

ER -