Impact of a mineral enriched, fiber complex on glycaemic response and satiation in healthy adults: a double-blind, crossover intervention study

TY - JOUR

T1 - Impact of a mineral enriched, fiber complex on glycaemic response and satiation in healthy adults: a double-blind, crossover intervention study

AU - Ancu, Oana

AU - Mackenzie, Richard W. A.

AU - Patterson, Michael

AU - Dsilva, Evone

AU - Yakubov, Gleb E.

AU - Haynes, Michael

AU - Kolida, Sofia

AU - Stephenson, Christopher G.

AU - Costabile, Adele

PY - 2025/8/1

Y1 - 2025/8/1

N2 - Purpose: To investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults. Methods: Using a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5–24.9 kg/m2) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro. Results: SBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone. Conclusions: These novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.

AB - Purpose: To investigate the effects of a chromium-enriched glucomannan-fructooligosaccharide complex (SB) on glycaemic and insulin responses, satiation, and hunger biomarkers in healthy adults. Methods: Using a double-blind, placebo-controlled, randomised crossover design, we assessed the acute impact of a single 3 g SB dose in 16 healthy adults (BMI 18.5–24.9 kg/m2) during a modified oral glucose tolerance test. On separate days, participants consumed 50 g dextrose or 50 g dextrose with 3 g SB (SBD). Blood glucose and insulin were analysed over 2.5 h. Hunger, fullness, and desire to eat were assessed via visual analogue scales. Additionally, the impact of SB on gastric viscosity was assessed in vitro. Results: SBD intake significantly reduced the insulin concentration compared to dextrose alone at 45, 75, and 90 min post-intake. Additionally, SBD resulted in significantly greater fullness and a lower desire to eat at 75 min when compared to dextrose (p < 0.05). Although hunger increased over time for both interventions, SBD led to lower hunger, desire to eat, and food desire scores compared to dextrose at 150 min (p < 0.05). The viscosity of SB, even when combined with dextrose, was significantly higher compared to dextrose alone. Conclusions: These novel findings suggest that SB can modulate insulin response and influence appetite regulation, highlighting its potential use in weight management strategies.

KW - Appetite regulation

KW - Insulin response

KW - Dietary supplements

KW - Weight management

U2 - 10.1007/s00394-025-03732-8

DO - 10.1007/s00394-025-03732-8

M3 - Article

SN - 1436-6207

VL - 64

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 5

ER -