In vivo effects of estrogen on human brain

William J Cutter; Michael Craig; Ray Norbury; Dene M Robertson; Malcolm Whitehead; Declan G Murphy

In vivo effects of estrogen on human brain

William J Cutter, Michael Craig, Ray Norbury, Dene M Robertson, Malcolm Whitehead, Declan G Murphy

School of Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Age-related brain disorders such as Alzheimer's disease (AD) are becoming increasingly prevalent. Estrogen replacement therapy (ERT) has shown potential both as a preventive measure and treatment for such disorders. Good evidence from basic science demonstrates that estrogen has multiple protective effects on neurons and neurotransmitter systems, and the effects of ERT can be demonstrated on the human brain using techniques such as functional neuroimaging. However, the evidence for estrogen's having a clinical role in the treatment and prevention of neuropsychiatric disorders is not well established. In this article we review research into the effects of estrogen on the human brain and we consider the role for ERT as a therapeutic tool.

Original language	English
Pages (from-to)	79-88
Number of pages	10
Journal	Annals of the New York Academy of Sciences
Volume	1007
Publication status	Published - Dec 2003

Keywords

Alzheimer Disease
Animals
Brain
Estrogen Replacement Therapy
Estrogens
Humans
Mental Disorders

Cite this

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title = "In vivo effects of estrogen on human brain",

abstract = "Age-related brain disorders such as Alzheimer's disease (AD) are becoming increasingly prevalent. Estrogen replacement therapy (ERT) has shown potential both as a preventive measure and treatment for such disorders. Good evidence from basic science demonstrates that estrogen has multiple protective effects on neurons and neurotransmitter systems, and the effects of ERT can be demonstrated on the human brain using techniques such as functional neuroimaging. However, the evidence for estrogen's having a clinical role in the treatment and prevention of neuropsychiatric disorders is not well established. In this article we review research into the effects of estrogen on the human brain and we consider the role for ERT as a therapeutic tool.",

keywords = "Alzheimer Disease, Animals, Brain, Estrogen Replacement Therapy, Estrogens, Humans, Mental Disorders",

author = "Cutter, {William J} and Michael Craig and Ray Norbury and Robertson, {Dene M} and Malcolm Whitehead and Murphy, {Declan G}",

year = "2003",

month = dec,

language = "English",

volume = "1007",

pages = "79--88",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

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TY - JOUR

T1 - In vivo effects of estrogen on human brain

AU - Cutter, William J

AU - Craig, Michael

AU - Norbury, Ray

AU - Robertson, Dene M

AU - Whitehead, Malcolm

AU - Murphy, Declan G

PY - 2003/12

Y1 - 2003/12

N2 - Age-related brain disorders such as Alzheimer's disease (AD) are becoming increasingly prevalent. Estrogen replacement therapy (ERT) has shown potential both as a preventive measure and treatment for such disorders. Good evidence from basic science demonstrates that estrogen has multiple protective effects on neurons and neurotransmitter systems, and the effects of ERT can be demonstrated on the human brain using techniques such as functional neuroimaging. However, the evidence for estrogen's having a clinical role in the treatment and prevention of neuropsychiatric disorders is not well established. In this article we review research into the effects of estrogen on the human brain and we consider the role for ERT as a therapeutic tool.

AB - Age-related brain disorders such as Alzheimer's disease (AD) are becoming increasingly prevalent. Estrogen replacement therapy (ERT) has shown potential both as a preventive measure and treatment for such disorders. Good evidence from basic science demonstrates that estrogen has multiple protective effects on neurons and neurotransmitter systems, and the effects of ERT can be demonstrated on the human brain using techniques such as functional neuroimaging. However, the evidence for estrogen's having a clinical role in the treatment and prevention of neuropsychiatric disorders is not well established. In this article we review research into the effects of estrogen on the human brain and we consider the role for ERT as a therapeutic tool.

KW - Alzheimer Disease

KW - Animals

KW - Brain

KW - Estrogen Replacement Therapy

KW - Estrogens

KW - Humans

KW - Mental Disorders

M3 - Article

C2 - 14993042

SN - 0077-8923

VL - 1007

SP - 79

EP - 88

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -