Neuropsychiatric drug development: Perspectives on the current landscape, opportunities and potential future directions

Simon Loiodice, Fulvio D'Acquisto, Pim Drinkenburg, Christian Suojanen, Pierre-Michel Llorca, Husseini K Manji

Research output: Contribution to journalReview articlepeer-review

Abstract

Mental health represents a major challenge to our societies. One key difficulty associated with neuropsychiatric drug development is the lack of connection between the underlying biology and the disease. Nevertheless, there is growing optimism in this field with recent drug approvals (the first in decades) and renewed interest from pharmaceutical companies and investors. Here we review some of the most promising drug discovery and development endeavors currently deployed by industry. We also present elements illustrating the renewed interest from key stakeholders in neuropsychiatric drug development and provide potential future directions in this field.

Original languageEnglish
Pages (from-to)104255
JournalDrug discovery today
Early online date28 Nov 2024
DOIs
Publication statusE-pub ahead of print - 28 Nov 2024

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