Perinatal, obstetric and parental risk factors for asthma in the offspring throughout childhood: a longitudinal cohort study

Rafael A. Caparros-Gonzalez, Cecilia Essau, Jean-Philippe Gouin, Andres Pemau, Alejandra Galvez-Merlin, Alejandro de la Torre-Luque

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    © 2023, Walter de Gruyter GmbH, Berlin/Boston. The attached document (embargoed until 19/06/2024) is an author produced version of a paper published in Journal of Perintal Medicine uploaded in accordance with the publisher’s self-archiving policy. The final published version (version of record) is available online at the link. Some minor differences between this version and the final published version may remain. We suggest you refer to the final published version should you wish to cite from it. 

    Objectives Asthma is a common chronic and burdensome disease which typically begins in childhood. The aim of this study was to assess perinatal and obstetric factors which may increase the risk of developing asthma in the offspring. Methods Data from five consecutive waves (n=7,073 children, from birth to 15 years old) from a nationally-representative birth cohort of people born in the United Kingdom between 2000 and 2002, the Millennium Cohort Study (MCS), were used. The Kaplan–Meier survival curve was used to graphically display the risk of developing asthma from early childhood to adolescence. The Z-based Wald test was used to prove significant covariate loading. Results Cox regression analyzing the influence of covariates on asthma development risk showed a significant likelihood ratio test, χ2(18)=899.30, p<0.01. A parent with asthma (OR=2.02, p<0.01), a younger maternal age at delivery (OR=0.98, p<0.05), and the use of assisted reproductive technology (OR=1.43, p<0.05) were associated with an increased risk of developing asthma in the offspring. Conclusions Perinatal factors (a younger maternal age, assisted reproductive technology) and a parental factor (a parent with asthma) increased the risk for developing asthma in the offspring.
    Original languageEnglish
    JournalJournal of Perinatal Medicine
    Issue number0
    Early online date19 Jun 2023
    Publication statusE-pub ahead of print - 19 Jun 2023


    • Obstetrics and Gynecology
    • Pediatrics, Perinatology and Child Health

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