PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency

TY - JOUR

T1 - PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency

AU - Xu, Benjamin

AU - Sandrini, Marco

AU - Wang, Wen-Tung

AU - Smith, Jason F

AU - Sarlls, Joelle E

AU - Awosika, Oluwole

AU - Butman, John A

AU - Horwitz, Barry

AU - Cohen, Leonardo G

N1 - This work was supported by the Department of Defense through the Center for Neuroscience and Regenerative Medicine (G189AN and G189BK) and by the Intramural Research Program of the National Institute of Neurological Disorders and Stroke, and the National Institute on Deafness and Other Communication Disorders, at the National Institutes of Health.

PY - 2016/5/4

Y1 - 2016/5/4

N2 - Previous work using transcranial magnetic stimulation (TMS) demonstrated that the right presupplementary motor area (preSMA), a node in the fronto-basal-ganglia network, is critical for response inhibition. However, TMS influences interconnected regions, raising the possibility of a link between the preSMA activity and the functional connectivity within the network. To understand this relationship, we applied single-pulse TMS to the right preSMA during functional magnetic resonance imaging when the subjects were at rest to examine changes in neural activity and functional connectivity within the network in relation to the efficiency of response inhibition evaluated with a stop-signal task. The results showed that preSMA-TMS increased activation in the right inferior-frontal cortex (rIFC) and basal ganglia and modulated their task-free functional connectivity. Both the TMS-induced changes in the basal-ganglia activation and the functional connectivity between rIFC and left striatum, and of the overall network correlated with the efficiency of response inhibition and with the white-matter microstructure along the preSMA-rIFC pathway. These results suggest that the task-free functional and structural connectivity between the rIFCop and basal ganglia are critical to the efficiency of response inhibition. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.

AB - Previous work using transcranial magnetic stimulation (TMS) demonstrated that the right presupplementary motor area (preSMA), a node in the fronto-basal-ganglia network, is critical for response inhibition. However, TMS influences interconnected regions, raising the possibility of a link between the preSMA activity and the functional connectivity within the network. To understand this relationship, we applied single-pulse TMS to the right preSMA during functional magnetic resonance imaging when the subjects were at rest to examine changes in neural activity and functional connectivity within the network in relation to the efficiency of response inhibition evaluated with a stop-signal task. The results showed that preSMA-TMS increased activation in the right inferior-frontal cortex (rIFC) and basal ganglia and modulated their task-free functional connectivity. Both the TMS-induced changes in the basal-ganglia activation and the functional connectivity between rIFC and left striatum, and of the overall network correlated with the efficiency of response inhibition and with the white-matter microstructure along the preSMA-rIFC pathway. These results suggest that the task-free functional and structural connectivity between the rIFCop and basal ganglia are critical to the efficiency of response inhibition. Hum Brain Mapp, 2016. © 2016 Wiley Periodicals, Inc.

UR - http://doi.wiley.com/10.1002/hbm.23236

U2 - 10.1002/hbm.23236

DO - 10.1002/hbm.23236

M3 - Article

C2 - 27144466

SN - 1065-9471

JO - HUMAN BRAIN MAPPING

JF - HUMAN BRAIN MAPPING

ER -