Abstract
According to Aristotle, "The whole is greater than the sum of its parts" and yet, although a long time has passed still, we seem to struggle to accept this universal concept. Searching in the literature for the biological function of Annexin-A1, one would find a wealth of information on its homeostatic and protective anti-inflammatory effects. However, very little has been said on its emerging role in a wide variety of pathological conditions ranging from cancer to autoimmunity. In this commentary, we will focus our attention on this novel pro-inflammatory and pathogenic "dark side" of Annexin-A1. We will summarize our current understanding of the signaling pathways regulated by this protein and link it to clinical and experimental evidences. Finally we will discuss assets and limitations of Annexin-A1 therapeutic strategies. Most importantly, we hope that this commentary will provide scientific support to "controversial" findings one might encounter while studying this fascinating protein.
| Original language | English |
|---|---|
| Pages (from-to) | 1213-8 |
| Number of pages | 6 |
| Journal | BIOCHEMICAL PHARMACOLOGY |
| Volume | 85 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1 May 2013 |
Keywords
- Animals
- Annexin A1
- Autoimmune Diseases
- Colitis, Ulcerative
- Cystic Fibrosis
- Humans
- Inflammation
- Neoplasms
- Signal Transduction
- Journal Article