Pro-inflammatory and pathogenic properties of Annexin-A1: the whole is greater than the sum of its parts

Fulvio D'Acquisto, Giuseppa Piras, Lorenza Rattazzi

Research output: Contribution to journalArticlepeer-review


According to Aristotle, "The whole is greater than the sum of its parts" and yet, although a long time has passed still, we seem to struggle to accept this universal concept. Searching in the literature for the biological function of Annexin-A1, one would find a wealth of information on its homeostatic and protective anti-inflammatory effects. However, very little has been said on its emerging role in a wide variety of pathological conditions ranging from cancer to autoimmunity. In this commentary, we will focus our attention on this novel pro-inflammatory and pathogenic "dark side" of Annexin-A1. We will summarize our current understanding of the signaling pathways regulated by this protein and link it to clinical and experimental evidences. Finally we will discuss assets and limitations of Annexin-A1 therapeutic strategies. Most importantly, we hope that this commentary will provide scientific support to "controversial" findings one might encounter while studying this fascinating protein.

Original languageEnglish
Pages (from-to)1213-8
Number of pages6
Issue number9
Publication statusPublished - 1 May 2013


  • Animals
  • Annexin A1
  • Autoimmune Diseases
  • Colitis, Ulcerative
  • Cystic Fibrosis
  • Humans
  • Inflammation
  • Neoplasms
  • Signal Transduction
  • Journal Article

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