Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate

Monica Deiana; Antonella Rosa; Giulia Corona; Angela Atzeri; Alessandra Incani; Francesco Visioli; M Paola Melis; M Assunta Dessì

doi:10.1016/j.fct.2007.06.028

Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate

Monica Deiana, Antonella Rosa, Giulia Corona, Angela Atzeri, Alessandra Incani, Francesco Visioli, M Paola Melis, M Assunta Dessì

Research output: Contribution to journal › Article › peer-review

Abstract

The phenolic fraction of virgin olive oil exerts preventive effects against reactive oxygen species mediated degenerative diseases. To investigate its action as inhibitor of lipid peroxidation in vivo, we treated Wistar rats with olive oil minor polar components (MPC) (25-50 mg/kg bw) prior to the administration of a sublethal dose (15 mg Fe/kg bw) of ferric-nitrilotriacetate (Fe-NTA). Intraperitoneal injection (i.p.) of Fe-NTA lead to increased oxidative stress associated with extensive peroxidation of membrane lipids in plasma, kidney, and liver of treated rats. Fe-NTA treatment induced a significant decrease of the major oxidizable membrane lipids, alpha-tocopherol, fatty acids and cholesterol, together with an increase of fatty acids hydroperoxides (HP) and 7-ketocholesterol (7-keto). I.p. administration of MPC significantly inhibited fatty acids and cholesterol oxidation, and reduced the levels of HP and 7-keto. In summary, MPC administration protects organs against lipid peroxidation and conserves the endogenous alpha-tocopherol.

Original language	English
Pages (from-to)	2434-40
Number of pages	7
Journal	FOOD AND CHEMICAL TOXICOLOGY
Volume	45
Issue number	12
DOIs	https://doi.org/10.1016/j.fct.2007.06.028
Publication status	Published - Dec 2007

Keywords

Animals
Dose-Response Relationship, Drug
Ferric Compounds
Injections, Intraperitoneal
Kidney
Lipid Peroxidation
Liver
Male
Nitrilotriacetic Acid
Olive Oil
Phytotherapy
Plant Oils
Protective Agents
Rats
Rats, Wistar

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10.1016/j.fct.2007.06.028

Cite this

@article{d837806d6ebc4d899c386439a685d52e,

title = "Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate",

abstract = "The phenolic fraction of virgin olive oil exerts preventive effects against reactive oxygen species mediated degenerative diseases. To investigate its action as inhibitor of lipid peroxidation in vivo, we treated Wistar rats with olive oil minor polar components (MPC) (25-50 mg/kg bw) prior to the administration of a sublethal dose (15 mg Fe/kg bw) of ferric-nitrilotriacetate (Fe-NTA). Intraperitoneal injection (i.p.) of Fe-NTA lead to increased oxidative stress associated with extensive peroxidation of membrane lipids in plasma, kidney, and liver of treated rats. Fe-NTA treatment induced a significant decrease of the major oxidizable membrane lipids, alpha-tocopherol, fatty acids and cholesterol, together with an increase of fatty acids hydroperoxides (HP) and 7-ketocholesterol (7-keto). I.p. administration of MPC significantly inhibited fatty acids and cholesterol oxidation, and reduced the levels of HP and 7-keto. In summary, MPC administration protects organs against lipid peroxidation and conserves the endogenous alpha-tocopherol.",

keywords = "Animals, Dose-Response Relationship, Drug, Ferric Compounds, Injections, Intraperitoneal, Kidney, Lipid Peroxidation, Liver, Male, Nitrilotriacetic Acid, Olive Oil, Phytotherapy, Plant Oils, Protective Agents, Rats, Rats, Wistar",

author = "Monica Deiana and Antonella Rosa and Giulia Corona and Angela Atzeri and Alessandra Incani and Francesco Visioli and {Paola Melis}, M and {Assunta Dess{\`i}}, M",

year = "2007",

month = dec,

doi = "10.1016/j.fct.2007.06.028",

language = "English",

volume = "45",

pages = "2434--40",

journal = "FOOD AND CHEMICAL TOXICOLOGY",

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TY - JOUR

T1 - Protective effect of olive oil minor polar components against oxidative damage in rats treated with ferric-nitrilotriacetate

AU - Deiana, Monica

AU - Rosa, Antonella

AU - Corona, Giulia

AU - Atzeri, Angela

AU - Incani, Alessandra

AU - Visioli, Francesco

AU - Paola Melis, M

AU - Assunta Dessì, M

PY - 2007/12

Y1 - 2007/12

N2 - The phenolic fraction of virgin olive oil exerts preventive effects against reactive oxygen species mediated degenerative diseases. To investigate its action as inhibitor of lipid peroxidation in vivo, we treated Wistar rats with olive oil minor polar components (MPC) (25-50 mg/kg bw) prior to the administration of a sublethal dose (15 mg Fe/kg bw) of ferric-nitrilotriacetate (Fe-NTA). Intraperitoneal injection (i.p.) of Fe-NTA lead to increased oxidative stress associated with extensive peroxidation of membrane lipids in plasma, kidney, and liver of treated rats. Fe-NTA treatment induced a significant decrease of the major oxidizable membrane lipids, alpha-tocopherol, fatty acids and cholesterol, together with an increase of fatty acids hydroperoxides (HP) and 7-ketocholesterol (7-keto). I.p. administration of MPC significantly inhibited fatty acids and cholesterol oxidation, and reduced the levels of HP and 7-keto. In summary, MPC administration protects organs against lipid peroxidation and conserves the endogenous alpha-tocopherol.

AB - The phenolic fraction of virgin olive oil exerts preventive effects against reactive oxygen species mediated degenerative diseases. To investigate its action as inhibitor of lipid peroxidation in vivo, we treated Wistar rats with olive oil minor polar components (MPC) (25-50 mg/kg bw) prior to the administration of a sublethal dose (15 mg Fe/kg bw) of ferric-nitrilotriacetate (Fe-NTA). Intraperitoneal injection (i.p.) of Fe-NTA lead to increased oxidative stress associated with extensive peroxidation of membrane lipids in plasma, kidney, and liver of treated rats. Fe-NTA treatment induced a significant decrease of the major oxidizable membrane lipids, alpha-tocopherol, fatty acids and cholesterol, together with an increase of fatty acids hydroperoxides (HP) and 7-ketocholesterol (7-keto). I.p. administration of MPC significantly inhibited fatty acids and cholesterol oxidation, and reduced the levels of HP and 7-keto. In summary, MPC administration protects organs against lipid peroxidation and conserves the endogenous alpha-tocopherol.

KW - Animals

KW - Dose-Response Relationship, Drug

KW - Ferric Compounds

KW - Injections, Intraperitoneal

KW - Kidney

KW - Lipid Peroxidation

KW - Liver

KW - Male

KW - Nitrilotriacetic Acid

KW - Olive Oil

KW - Phytotherapy

KW - Plant Oils

KW - Protective Agents

KW - Rats

KW - Rats, Wistar

U2 - 10.1016/j.fct.2007.06.028

DO - 10.1016/j.fct.2007.06.028

M3 - Article

C2 - 17686562

SN - 0278-6915

VL - 45

SP - 2434

EP - 2440

JO - FOOD AND CHEMICAL TOXICOLOGY

JF - FOOD AND CHEMICAL TOXICOLOGY

IS - 12

ER -