Risk for depression is associated with neural biases in emotional categorisation

TY - JOUR

T1 - Risk for depression is associated with neural biases in emotional categorisation

AU - Chan, Stella W Y

AU - Harmer, Catherine J

AU - Goodwin, Guy M

AU - Norbury, Ray

PY - 2008/10

Y1 - 2008/10

N2 - Negative biases in emotional processing are a major characteristic of depression. Recent research has shown that such negative biases are evident in high risk individuals even in the absence of personal history of depression, suggesting that they may serve as key vulnerability markers of depression. However, the neural basis of these behavioural observations has not been fully explored. This study therefore aimed to (1) illustrate the neural processes involved in the categorisation of emotional personality-trait words; and (2) examine whether these neural mechanisms are biased towards negative information in high risk individuals. Risk for depression was defined by high neuroticism (N). We recruited a sample of high risk (high N) and low risk (low N) never-depressed young adults. Functional magnetic resonance imaging (fMRI) was acquired during the categorisation and memory for positive and negative self-referent personality-trait words (e.g. honest, rude). High risk volunteers showed greater responses in the right superior parietal cortex than low risk volunteers specifically during the categorisation of negative words. Moreover, neuroticism score was positively correlated with neural responses in the left anterior cingulate during the categorisation of negative words but negatively correlated within the same region during the retrieval of these words. These results highlight a role of the fronto-parietal circuitry in emotional processing and further suggest that negative biases in these neural processes may be involved in risk for depression.

AB - Negative biases in emotional processing are a major characteristic of depression. Recent research has shown that such negative biases are evident in high risk individuals even in the absence of personal history of depression, suggesting that they may serve as key vulnerability markers of depression. However, the neural basis of these behavioural observations has not been fully explored. This study therefore aimed to (1) illustrate the neural processes involved in the categorisation of emotional personality-trait words; and (2) examine whether these neural mechanisms are biased towards negative information in high risk individuals. Risk for depression was defined by high neuroticism (N). We recruited a sample of high risk (high N) and low risk (low N) never-depressed young adults. Functional magnetic resonance imaging (fMRI) was acquired during the categorisation and memory for positive and negative self-referent personality-trait words (e.g. honest, rude). High risk volunteers showed greater responses in the right superior parietal cortex than low risk volunteers specifically during the categorisation of negative words. Moreover, neuroticism score was positively correlated with neural responses in the left anterior cingulate during the categorisation of negative words but negatively correlated within the same region during the retrieval of these words. These results highlight a role of the fronto-parietal circuitry in emotional processing and further suggest that negative biases in these neural processes may be involved in risk for depression.

KW - Adolescent

KW - Adult

KW - Brain Mapping

KW - Cerebral Cortex

KW - Depression

KW - Depressive Disorder

KW - Discrimination (Psychology)

KW - Disease Susceptibility

KW - Emotions

KW - Female

KW - Functional Laterality

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Neurotic Disorders

KW - Reference Values

KW - Risk Assessment

KW - Verbal Behavior

U2 - 10.1016/j.neuropsychologia.2008.05.030

DO - 10.1016/j.neuropsychologia.2008.05.030

M3 - Article

C2 - 18601940

SN - 0028-3932

VL - 46

SP - 2896

EP - 2903

JO - NEUROPSYCHOLOGIA

JF - NEUROPSYCHOLOGIA

IS - 12

ER -