• James Gilleen
  • Marcello Tesse
  • Tjasa Velikonja
  • Mark Weiser
  • Michael Davidson
  • Abraham Reichenberg
Background: Cognitive deficits, particularly in processing speed, are widely recognized as a critical feature of schizophrenia, and are also present across schizophrenia spectrum disorders. A number of important confounders, however, such as hospitalization effects and antipsychotic medication, have been shown to affect processing speed, causing debate as to the core cognitive deficits of schizophrenia. The study of individuals who are not clinically psychotic but have schizotypal traits allows investigation of cognitive deficits associated with both positive and negative schizotypy dimensions while excluding potential confounds. Methods: A population-based community sample of 242 healthy adult volunteers assessed using the Structured Interview of Schizotypy – Revised (SIS-R) scale, and a neuropsychological testing battery that included measures of verbal ability, visual and verbal memory, verbal fluency, working memory, executive functions and processing speed. Participants were classified in High or Low Positive Schizotypy (H-PST or L-PST), High or Low Paranoia-like traits (H-PAR or L-PAR) and High or Low Negative Schizotypy (H-NST or L-NST) groups, respectively. Results: Individuals with H-PST performed significantly (p<0.05) worse than L-PST on measures of processing speed and executive functions. Processing speed deficits were also observed in individuals with H-PAR compared to L-PAR (p<0.05). There were no statistically significant differences in neuropsychological performance between H-NST and L-NST on any measure.Conclusions: In a population-based community sample, individuals with high positive schizotypal traits or paranoia-like traits show impairments in processing speed. Consistent with a dimensional view of psychosis, this supports the hypothesis that processing speed represents a core deficit of schizophrenia-like mental states.
Original languageEnglish
JournalSchizophrenia Research
StateSubmitted - 25 Jan 2019

ID: 1196345