Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

Astrid Hauge Evans, Aileen J. King, Danielle Carmignac, Carolyn C. Richardson, Iain C. Robinson, Malcolm J. Low, Michael R. Christie, Shanta J. Persaud, Peter M. Jones

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE-Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in
Original languageEnglish
Pages (from-to)403-411
JournalDIABETES
Volume58
Issue number2
DOIs
Publication statusPublished - 2009

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