Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

Astrid Hauge Evans; Aileen J. King; Danielle Carmignac; Carolyn C. Richardson; Iain C. Robinson; Malcolm J. Low; Michael R. Christie; Shanta J. Persaud; Peter M. Jones

doi:10.2337/db08-0792

Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

Astrid Hauge Evans
, Aileen J. King
, Danielle Carmignac
, Carolyn C. Richardson
, Iain C. Robinson
, Malcolm J. Low
, Michael R. Christie
, Shanta J. Persaud
, Peter M. Jones

School of Life and Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE-Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in

Original language	English
Pages (from-to)	403-411
Journal	DIABETES
Volume	58
Issue number	2
DOIs	https://doi.org/10.2337/db08-0792
Publication status	Published - 2009

Access to Document

10.2337/db08-0792

http://dx.doi.org/10.2337/db08-0792

Cite this

@article{ac4734e84e8f4cb1a837d152a890588e,

title = "Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function",

abstract = "OBJECTIVE-Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in",

author = "\{Hauge Evans\}, Astrid and King, \{Aileen J.\} and Danielle Carmignac and Richardson, \{Carolyn C.\} and Robinson, \{Iain C.\} and Low, \{Malcolm J.\} and Christie, \{Michael R.\} and Persaud, \{Shanta J.\} and Jones, \{Peter M.\}",

year = "2009",

doi = "10.2337/db08-0792",

language = "English",

volume = "58",

pages = "403--411",

journal = "DIABETES",

issn = "0012-1797",

publisher = "American Diabetes Association",

number = "2",

}

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T1 - Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

AU - Hauge Evans, Astrid

AU - King, Aileen J.

AU - Carmignac, Danielle

AU - Richardson, Carolyn C.

AU - Robinson, Iain C.

AU - Low, Malcolm J.

AU - Christie, Michael R.

AU - Persaud, Shanta J.

AU - Jones, Peter M.

PY - 2009

Y1 - 2009

N2 - OBJECTIVE-Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in

AB - OBJECTIVE-Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in

U2 - 10.2337/db08-0792

DO - 10.2337/db08-0792

M3 - Article

SN - 0012-1797

VL - 58

SP - 403

EP - 411

JO - DIABETES

JF - DIABETES

IS - 2

ER -