The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

Norlida M Daud; Nurhafzan A Ismail; Elizabeth L Thomas; Julie A Fitzpatrick; Jimmy D Bell; Jonathan R Swann; Adele Costabile; Caroline E Childs; Camilla Pedersen; Anthony P Goldstone; Gary S Frost

doi:10.1002/oby.20754

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

Norlida M Daud, Nurhafzan A Ismail, Elizabeth L Thomas, Julie A Fitzpatrick, Jimmy D Bell, Jonathan R Swann, Adele Costabile, Caroline E Childs, Camilla Pedersen, Anthony P Goldstone, Gary S Frost

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.

METHODS: In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day(-1) oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation.

RESULTS: Oligofructose increased breath hydrogen (P < 0.0001), late acetate concentrations (P = 0.024), tended to increase total area under the curve (tAUC)420 mins peptide YY (PYY) (P = 0.056) and reduced tAUC450 mins hunger (P = 0.034) and motivation to eat (P = 0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon-like peptide 1 (GLP-1) (P = 0.006) in the cellulose group and a decrease in EI during ad libitum meal in both groups.

CONCLUSIONS: Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP-1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.

Original language	English
Pages (from-to)	1430-8
Number of pages	9
Journal	Obesity
Volume	22
Issue number	6
DOIs	https://doi.org/10.1002/oby.20754
Publication status	Published - Jun 2014

Keywords

Adiposity
Adult
Appetite
Appetite Regulation
Area Under Curve
Blood Glucose
Body Weight
Cellulose
Dietary Fiber
Dietary Supplements
Energy Intake
Fatty Acids
Female
Glucagon-Like Peptide 1
Healthy Volunteers
Humans
Insulin
Male
Middle Aged
Obesity
Oligosaccharides
Overweight
Patient Compliance
Peptide YY
Single-Blind Method
Young Adult

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10.1002/oby.20754

Adele Costabile
- School of Life and Health Sciences - Clinical Nutrition and Microbiome
- Centre for Integrated Research in Life and Health Sciences
Person: Academic

Cite this

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title = "The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity",

abstract = "OBJECTIVE: To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.METHODS: In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day(-1) oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation.RESULTS: Oligofructose increased breath hydrogen (P < 0.0001), late acetate concentrations (P = 0.024), tended to increase total area under the curve (tAUC)420 mins peptide YY (PYY) (P = 0.056) and reduced tAUC450 mins hunger (P = 0.034) and motivation to eat (P = 0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon-like peptide 1 (GLP-1) (P = 0.006) in the cellulose group and a decrease in EI during ad libitum meal in both groups.CONCLUSIONS: Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP-1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.",

keywords = "Adiposity, Adult, Appetite, Appetite Regulation, Area Under Curve, Blood Glucose, Body Weight, Cellulose, Dietary Fiber, Dietary Supplements, Energy Intake, Fatty Acids, Female, Glucagon-Like Peptide 1, Healthy Volunteers, Humans, Insulin, Male, Middle Aged, Obesity, Oligosaccharides, Overweight, Patient Compliance, Peptide YY, Single-Blind Method, Young Adult",

author = "Daud, \{Norlida M\} and Ismail, \{Nurhafzan A\} and Thomas, \{Elizabeth L\} and Fitzpatrick, \{Julie A\} and Bell, \{Jimmy D\} and Swann, \{Jonathan R\} and Adele Costabile and Childs, \{Caroline E\} and Camilla Pedersen and Goldstone, \{Anthony P\} and Frost, \{Gary S\}",

note = "{\textcopyright} 2014 The Obesity Society.",

year = "2014",

month = jun,

doi = "10.1002/oby.20754",

language = "English",

volume = "22",

pages = "1430--8",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley",

number = "6",

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TY - JOUR

T1 - The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

AU - Daud, Norlida M

AU - Ismail, Nurhafzan A

AU - Thomas, Elizabeth L

AU - Fitzpatrick, Julie A

AU - Bell, Jimmy D

AU - Swann, Jonathan R

AU - Costabile, Adele

AU - Childs, Caroline E

AU - Pedersen, Camilla

AU - Goldstone, Anthony P

AU - Frost, Gary S

PY - 2014/6

Y1 - 2014/6

N2 - OBJECTIVE: To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.METHODS: In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day(-1) oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation.RESULTS: Oligofructose increased breath hydrogen (P < 0.0001), late acetate concentrations (P = 0.024), tended to increase total area under the curve (tAUC)420 mins peptide YY (PYY) (P = 0.056) and reduced tAUC450 mins hunger (P = 0.034) and motivation to eat (P = 0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon-like peptide 1 (GLP-1) (P = 0.006) in the cellulose group and a decrease in EI during ad libitum meal in both groups.CONCLUSIONS: Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP-1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.

AB - OBJECTIVE: To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.METHODS: In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day(-1) oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation.RESULTS: Oligofructose increased breath hydrogen (P < 0.0001), late acetate concentrations (P = 0.024), tended to increase total area under the curve (tAUC)420 mins peptide YY (PYY) (P = 0.056) and reduced tAUC450 mins hunger (P = 0.034) and motivation to eat (P = 0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon-like peptide 1 (GLP-1) (P = 0.006) in the cellulose group and a decrease in EI during ad libitum meal in both groups.CONCLUSIONS: Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP-1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.

KW - Adiposity

KW - Adult

KW - Appetite

KW - Appetite Regulation

KW - Area Under Curve

KW - Blood Glucose

KW - Body Weight

KW - Cellulose

KW - Dietary Fiber

KW - Dietary Supplements

KW - Energy Intake

KW - Fatty Acids

KW - Female

KW - Glucagon-Like Peptide 1

KW - Healthy Volunteers

KW - Humans

KW - Insulin

KW - Male

KW - Middle Aged

KW - Obesity

KW - Oligosaccharides

KW - Overweight

KW - Patient Compliance

KW - Peptide YY

KW - Single-Blind Method

KW - Young Adult

U2 - 10.1002/oby.20754

DO - 10.1002/oby.20754

M3 - Article

C2 - 24715424

SN - 1930-7381

VL - 22

SP - 1430

EP - 1438

JO - Obesity

JF - Obesity

IS - 6

ER -

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

Abstract

Keywords

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Adele Costabile

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