Abstract
Evidence suggests that a combination of oxidative stress, neuroinflammation and the formation endogenous neurotoxins
8 all contribute to the underlying neuronal death associated with neurodegenerative diseases. In this study we have investigated
9 the ability of the berry-derived flavonoids to protect against neuronal damage induced by neuroinflammation and the neurotoxin
10 5-S-cysteinyl-dopamine. The flavanols (+)-catechin and (–)-epicatechin, but not the anthocyanidin pelargonidin, were observed
11 to attenuate LPS/IFN--induced TNF- production in glial cells and associated neuronal injury. In contrast, pre-treatment of
12 primary cortical neuronswith pelargonidin, (+)-catechin and (–)-epicatechin (0.1 and 0.3 M) resulted in concentration-dependant
13 protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. Together these data suggest that berry-derived flavonoids may
14 offer some protection against the neuronal injury relevant to the aetiology of the Parkinson’s and Alzheimer’s diseases.
15 Keywords: Brain, neuroinflammation, flavonoids, Parkinson disease, neurotoxins
8 all contribute to the underlying neuronal death associated with neurodegenerative diseases. In this study we have investigated
9 the ability of the berry-derived flavonoids to protect against neuronal damage induced by neuroinflammation and the neurotoxin
10 5-S-cysteinyl-dopamine. The flavanols (+)-catechin and (–)-epicatechin, but not the anthocyanidin pelargonidin, were observed
11 to attenuate LPS/IFN--induced TNF- production in glial cells and associated neuronal injury. In contrast, pre-treatment of
12 primary cortical neuronswith pelargonidin, (+)-catechin and (–)-epicatechin (0.1 and 0.3 M) resulted in concentration-dependant
13 protection against 5-S-cysteinyl-dopamine-induced neurotoxicity. Together these data suggest that berry-derived flavonoids may
14 offer some protection against the neuronal injury relevant to the aetiology of the Parkinson’s and Alzheimer’s diseases.
15 Keywords: Brain, neuroinflammation, flavonoids, Parkinson disease, neurotoxins
| Original language | English |
|---|---|
| Pages (from-to) | 45-52 |
| Journal | Journal of Berry Research |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |