The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET

Paul Faulkner; Sudhakar Selvaraj; Alex Pine; Oliver D Howes; Jonathan P Roiser

doi:10.1007/s00213-013-3426-9

The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET

Paul Faulkner, Sudhakar Selvaraj, Alex Pine, Oliver D Howes, Jonathan P Roiser

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Abstract

RATIONALE: The serotonin (5-HT) system has been reported to be involved in decision-making. A key component of this neurotransmitter system is the 5-HT1A receptor, and research is beginning to show how this receptor can influence decision-making. However, this relationship has rarely been studied in humans.

OBJECTIVES: This study assessed whether individual variability in 5-HT1A availability correlates with decision-making in healthy volunteers.

METHODS: We measured regional availability of the 5-HT1A receptor in the hippocampal complex and striatum using positron emission tomography and correlated this with performance on two decision-making tasks measuring sensitivity to probability, rewards and punishments and temporal discounting, respectively.

RESULTS: No relationship between decision-making behaviour and 5-HT1A availability in the striatum was found. However, a positive correlation was detected between participants' 5-HT1A availability in the hippocampal complex and their sensitivity to the probability of winning. Furthermore, there was a negative correlation between the degree to which participants discounted future rewards and 5-HT1A availability in the hippocampal complex.

CONCLUSIONS: These data support a role for the 5-HT1A receptor in the aberrant decision-making that can occur in neuropsychiatric disorders such as depression.

© 2014, The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/

Original language	English
Pages (from-to)	2579-86
Number of pages	8
Journal	Psychopharmacology
Volume	231
Issue number	13
DOIs	https://doi.org/10.1007/s00213-013-3426-9
Publication status	Published - Jul 2014

Keywords

Adult
Corpus Striatum
Decision Making
Delay Discounting
Female
Hippocampus
Humans
Male
Middle Aged
Positron-Emission Tomography
Probability
Punishment
Receptor, Serotonin, 5-HT1A
Reward
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

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10.1007/s00213-013-3426-9

The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PETFinal published version, 772 KBLicence: CC BY

Paul Faulkner
- School of Psychology - Associate Professor
- Centre for REsearch in Psychological Wellbeing
Person: Academic

Cite this

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title = "The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET",

abstract = "RATIONALE: The serotonin (5-HT) system has been reported to be involved in decision-making. A key component of this neurotransmitter system is the 5-HT1A receptor, and research is beginning to show how this receptor can influence decision-making. However, this relationship has rarely been studied in humans.OBJECTIVES: This study assessed whether individual variability in 5-HT1A availability correlates with decision-making in healthy volunteers.METHODS: We measured regional availability of the 5-HT1A receptor in the hippocampal complex and striatum using positron emission tomography and correlated this with performance on two decision-making tasks measuring sensitivity to probability, rewards and punishments and temporal discounting, respectively.RESULTS: No relationship between decision-making behaviour and 5-HT1A availability in the striatum was found. However, a positive correlation was detected between participants' 5-HT1A availability in the hippocampal complex and their sensitivity to the probability of winning. Furthermore, there was a negative correlation between the degree to which participants discounted future rewards and 5-HT1A availability in the hippocampal complex.CONCLUSIONS: These data support a role for the 5-HT1A receptor in the aberrant decision-making that can occur in neuropsychiatric disorders such as depression.{\textcopyright} 2014, The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/",

keywords = "Adult, Corpus Striatum, Decision Making, Delay Discounting, Female, Hippocampus, Humans, Male, Middle Aged, Positron-Emission Tomography, Probability, Punishment, Receptor, Serotonin, 5-HT1A, Reward, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't",

author = "Paul Faulkner and Sudhakar Selvaraj and Alex Pine and Howes, {Oliver D} and Roiser, {Jonathan P}",

year = "2014",

month = jul,

doi = "10.1007/s00213-013-3426-9",

language = "English",

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pages = "2579--86",

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T1 - The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET

AU - Faulkner, Paul

AU - Selvaraj, Sudhakar

AU - Pine, Alex

AU - Howes, Oliver D

AU - Roiser, Jonathan P

PY - 2014/7

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N2 - RATIONALE: The serotonin (5-HT) system has been reported to be involved in decision-making. A key component of this neurotransmitter system is the 5-HT1A receptor, and research is beginning to show how this receptor can influence decision-making. However, this relationship has rarely been studied in humans.OBJECTIVES: This study assessed whether individual variability in 5-HT1A availability correlates with decision-making in healthy volunteers.METHODS: We measured regional availability of the 5-HT1A receptor in the hippocampal complex and striatum using positron emission tomography and correlated this with performance on two decision-making tasks measuring sensitivity to probability, rewards and punishments and temporal discounting, respectively.RESULTS: No relationship between decision-making behaviour and 5-HT1A availability in the striatum was found. However, a positive correlation was detected between participants' 5-HT1A availability in the hippocampal complex and their sensitivity to the probability of winning. Furthermore, there was a negative correlation between the degree to which participants discounted future rewards and 5-HT1A availability in the hippocampal complex.CONCLUSIONS: These data support a role for the 5-HT1A receptor in the aberrant decision-making that can occur in neuropsychiatric disorders such as depression.© 2014, The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/

AB - RATIONALE: The serotonin (5-HT) system has been reported to be involved in decision-making. A key component of this neurotransmitter system is the 5-HT1A receptor, and research is beginning to show how this receptor can influence decision-making. However, this relationship has rarely been studied in humans.OBJECTIVES: This study assessed whether individual variability in 5-HT1A availability correlates with decision-making in healthy volunteers.METHODS: We measured regional availability of the 5-HT1A receptor in the hippocampal complex and striatum using positron emission tomography and correlated this with performance on two decision-making tasks measuring sensitivity to probability, rewards and punishments and temporal discounting, respectively.RESULTS: No relationship between decision-making behaviour and 5-HT1A availability in the striatum was found. However, a positive correlation was detected between participants' 5-HT1A availability in the hippocampal complex and their sensitivity to the probability of winning. Furthermore, there was a negative correlation between the degree to which participants discounted future rewards and 5-HT1A availability in the hippocampal complex.CONCLUSIONS: These data support a role for the 5-HT1A receptor in the aberrant decision-making that can occur in neuropsychiatric disorders such as depression.© 2014, The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/

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KW - Corpus Striatum

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KW - Delay Discounting

KW - Female

KW - Hippocampus

KW - Humans

KW - Male

KW - Middle Aged

KW - Positron-Emission Tomography

KW - Probability

KW - Punishment

KW - Receptor, Serotonin, 5-HT1A

KW - Reward

KW - Clinical Trial

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1007/s00213-013-3426-9

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SN - 0033-3158

VL - 231

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EP - 2586

JO - Psychopharmacology

JF - Psychopharmacology

IS - 13

ER -

The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET

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Paul Faulkner

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